[HTML][HTML] Nutrient regulation of signaling and transcription
GW Hart - Journal of Biological Chemistry, 2019 - ASBMB
In the early 1980s, while using purified glycosyltransferases to probe glycan structures on
surfaces of living cells in the murine immune system, we discovered a novel form of …
surfaces of living cells in the murine immune system, we discovered a novel form of …
[HTML][HTML] Elevated O-GlcNAcylation enhances pro-inflammatory Th17 function by altering the intracellular lipid microenvironment
Chronic, low-grade inflammation increases the risk for atherosclerosis, cancer, and
autoimmunity in diseases such as obesity and diabetes. Levels of CD4+ T helper 17 (Th17) …
autoimmunity in diseases such as obesity and diabetes. Levels of CD4+ T helper 17 (Th17) …
[HTML][HTML] eIF4G1 and carboxypeptidase E axis dysregulation in O-GlcNAc transferase–deficient pancreatic β-cells contributes to hyperproinsulinemia in mice
An early hallmark of type 2 diabetes is a failure of proinsulin-to-insulin processing in
pancreatic β-cells, resulting in hyperproinsulinemia. Proinsulin processing is quite sensitive …
pancreatic β-cells, resulting in hyperproinsulinemia. Proinsulin processing is quite sensitive …
Increased OGA expression and activity in leukocytes from patients with diabetes: correlation with inflammation markers
P Pagesy, C Tachet, A Mostefa-Kara… - Experimental and …, 2019 - thieme-connect.com
O-linked-β-N-Acetylglucosaminylation (O-GlcNAcylation), a reversible post-translational
modification involved in diabetic complications, is regulated by only two enzymes, O-linked …
modification involved in diabetic complications, is regulated by only two enzymes, O-linked …
MYPT1 O-GlcNAc modification controls the sensitivity of fibroblasts to sphingosine-1-phosphate mediated cellular contraction
Many intracellular proteins can be modified by N-acetylglucosamine, a posttranslational
modification known as O-GlcNAc. Because this modification is found on serine and …
modification known as O-GlcNAc. Because this modification is found on serine and …
The Role of Protein O-GlcNAcylation in Regulating Mitochondrial Function
JLN Wright - 2019 - search.proquest.com
The attachment of O-linked-N-acetylglucosamine (O-GlcNAc) to the serine/threonine
residues of proteins has emerged as an important regulatory mechanism in transcriptional …
residues of proteins has emerged as an important regulatory mechanism in transcriptional …