Increasing attention has been paid to the diseases of central nervous system (CNS). The
penetration efficiency of most CNS drugs into the brain parenchyma is rather limited due to …

The blood–brain barrier (BBB) plays a fundamental role in protecting the brain from toxic
substances and therefore also controls and restricts the entry of therapeutic agents. The …

Intranasal delivery has shown to circumvent blood-brain-barrier (BBB) and deliver the drugs
into the CNS at a higher rate and extent than other conventional routes. The mechanism of …

Restricted drug entry to the brain that is closely associated with the existence of the blood
brain barrier (BBB) has limited the accessibility of most potential active therapeutic …

Purpose. The present study is an attempt to develop a vitamin E loaded naringenin (NRG)
Nanoemulsion (NE) for direct nose‐to‐brain delivery for better management of Parkinson …

Epilepsy is the fourth most common global neurological problem, which can be considered a
spectrum disorder because of its various causes, seizure types, its ability to vary in severity …

Neuronal apoptosis induced by oxidative stress is one of the major pathological processes
involved in neurological impairment after hypoxic-ischemic encephalopathy (HIE). Ghrelin …

Blood-brain barrier (BBB) provides restrictions for the transportation of various therapeutic
agents to the brain. Efforts to directly target the brain by olfactory as well as trigeminal nerve …

Background: Multiple sclerosis (MS) is one of the most severe autoimmune disorder of the
central nervous system (CNS). Objective: The present research work was aimed to formulate …

Nasal delivery offers many benefits over other conventional routes of delivery (eg oral or
intravenous administration). Benefits include, among others, a fast onset of action, non …