AKI is a common complication of sepsis and is significantly associated with mortality. Sepsis
accounts for more than 50% of the cases of AKI, with a mortality rate of up to 40%. The …

Background The α2 agonists, dexmedetomidine and clonidine, are used as sedative drugs
during critical illness. These drugs may have anti-inflammatory effects, which might be …

Objectives: Propofol-based sedation may increase hemodynamic instability by decreasing
vascular tone and venous return. Incremental exogenous catecholamines doses may be …

Background Global and intra-renal perfusion and oxygenation may be affected by the choice
of anaesthetic. We compared the effects of isoflurane with those of propofol and fentanyl on …

Norepinephrine exacerbates renal medullary hypoxia in experimental septic acute kidney
injury. Here we examined whether dexmedetomidine, an α2-adrenergic agonist, can restore …

Renal tissue hypoxia has been implicated as a critical mediatory factor in multiple forms of
acute kidney injury (AKI), including in sepsis. In sepsis, whole-kidney measures of …

In experimental sepsis, the rapid development of renal medullary hypoxia precedes the
development of acute kidney injury (AKI) and may contribute to its pathogenesis. We …

Methods: In conscious sheep, with implanted renal and pulmonary artery flow probes, sepsis
was induced by infusion of live Escherichia coli. At 24 h, a high clinical dose of clonidine …

Vascular hypo-responsiveness to vasopressors during septic shock is a challenging
problem. This study is to test the hypothesis that reactive nitrogen species (RNS), such as …

Vasodilatory shock is a life-threatening syndrome in critically ill patients and is characterized
by severe hypotension and resultant tissue hypoperfusion. This shock state requires the use …