Abstract The Klotho proteins, αKlotho and βKlotho, are essential components of endocrine
fibroblast growth factor (FGF) receptor complexes, as they are required for the high-affinity …

In patients with chronic kidney disease (CKD), adverse outcomes such as systemic
inflammation and anemia are contributing pathologies which increase the risks for …

Fibroblast growth factor 23 (FGF 23) is mainly produced in the bone and, upon secretion,
forms a complex with a FGF receptor and coreceptor αKlotho. FGF 23 can exert several …

The Fibroblast Growth Factor 21 (FGF21) is considered an attractive therapeutic target for
obesity and obesity-related disorders due to its beneficial effects in lipid and carbohydrate …

The development of Gonadotropin releasing hormone-1 (GnRH) neurons is important for a
functional reproduction system in vertebrates. Disruption of GnRH results in hypogonadism …

Abstract Fibroblast growth factor 23 (FGF23), one of the endocrine fibroblast growth factors,
is a principal regulator in the maintenance of serum phosphorus concentration. Binding to its …

Three members of the fibroblast growth factor (FGF) family, FGF19, FGF21 and FGF23, are
different from the other members in two major aspects. First, they are actually not growth …

Nonalcoholic steatohepatitis (NASH) is within the spectrum of nonalcoholic fatty liver
disease (NAFLD) and can progress to fibrosis, cirrhosis, and even hepatocellular carcinoma …

Accelerated vascular aging is a condition that occurs as a complication of several highly
prevalent inflammatory conditions such as chronic kidney disease, cancer, HIV infection and …

Bariatric surgery has proven to be the most effective treatment for controlling hyperglycemia
in severely obese patients with diabetes. We show that fibroblast growth factor 19 (FGF19), a …