[HTML][HTML] Micronuclei and genome chaos: changing the system inheritance

CJ Ye, Z Sharpe, S Alemara, S Mackenzie, G Liu… - Genes, 2019 - mdpi.com
Micronuclei research has regained its popularity due to the realization that genome chaos, a
rapid and massive genome re-organization under stress, represents a major common …

Occupational exposure to formaldehyde and early biomarkers of cancer risk, immunotoxicity and susceptibility

S Costa, C Costa, J Madureira, V Valdiglesias… - Environmental …, 2019 - Elsevier
Formaldehyde (FA) is a high-volume production chemical manufactured worldwide to which
many people are exposed to both environmentally and occupationally. FA was recently …

[HTML][HTML] Chromosomes missegregated into micronuclei contribute to chromosomal instability by missegregating at the next division

B He, N Gnawali, AW Hinman, AJ Mattingly… - Oncotarget, 2019 - ncbi.nlm.nih.gov
Micronuclei (MNi) are extranuclear DNA-containing structures that form upon mitotic exit
from unsegregated chromosome fragments or anaphase lagging (whole) chromosomes …

Micronucleus cytome assays in human lymphocytes and buccal cells

C Bolognesi, M Fenech - Genotoxicity Assessment: Methods and …, 2019 - Springer
The micronucleus (MN) assay, applied in different surrogate tissues, is one of the best
validated cytogenetic techniques for evaluating chromosomal damage in humans. The …

Genetic damage in human populations at mining sites in the upper basin of the San Jorge River, Colombia

Á Cruz-Esquivel, J Marrugo-Negrete… - … Science and Pollution …, 2019 - Springer
Contamination with mining wastes affects the environmental health and public, especially
the human populations that live in these environments. The aim of this study was to evaluate …

Mechanisms by which genotoxins cause micronuclei and other nuclear anomalies

M Fenech - 2019 - books.rsc.org
Normal eukaryotic cells contain a single nucleus. However, abnormal small nuclei known as
micronuclei (MN), additional to the main nucleus, may occur in cells that are exposed to …

“Normal values” for the lymphocyte cytokinesis-block micronucleus cytome parameters: Repeatability and reproducibility in a healthy reference population

C Bolognesi, L Bonelli, A Compalati, V Ferla… - Science of The Total …, 2019 - Elsevier
The micronucleus test in peripheral blood lymphocytes is the most widely validated
technique to evaluate the DNA damage and chromosomal instability in human populations …

Comparative study of micronucleus assays and dicentric plus ring chromosomes for dose assessment in particular cases of partial-body exposure

ME Mendes, JCG Mendonça… - … Journal of Radiation …, 2019 - Taylor & Francis
Purpose: The goal was to compare the micronucleus (MN) and dicentric plus ring
chromosomes (D+ R) assays for dose assessment in cases of partial body irradiations (PBI) …

[HTML][HTML] Phorate triggers oxidative stress and mitochondrial dysfunction to enhance micronuclei generation and DNA damage in human lymphocytes

Q Saquib, M Faisal, SM Ansari, R Wahab - Saudi Journal of Biological …, 2019 - Elsevier
Herein, we studied phorate for its toxicological effects in human lymphocytes. Phorate
treatment for 3 h has induced significant increase in the lymphocytic DNA damage …

Micronuclei frequency in peripheral blood lymphocytes and levels of anti-p53 autoantibodies in serum of residents of Kowary city regions (Poland) with elevated …

K Walczak, J Olszewski, K Domeradzka-Gajda… - … /Genetic Toxicology and …, 2019 - Elsevier
Introduction Ninety four residents of Kowary city (Poland) have been investigated for
environmental radon exposure that ranged from 0.24 WLM to 9.6 WLM (activity …