Restless legs syndrome (RLS) is a common sensorimotor disorder, whose basic
components include a sensory experience, akathisia, and a sleep-related motor sign …

Increasing evidence suggests that regular consumption of coffee, tea and dark chocolate
(cacao) can promote brain health and may reduce the risk of age-related neurodegenerative …

While neuronal loss has long been considered as the main contributor to age-related
cognitive decline, these alterations are currently attributed to gradual synaptic dysfunction …

At present, clinical interest in the plant-derived cannabinoid compound cannabidiol (CBD) is
rising exponentially, since it displays multiple therapeutic properties. In addition, CBD can …

Neuroprotective M2‐skewed microglia appear as promising to alter the course of
neurodegenerative diseases and G protein‐coupled receptors (GPCRs) are potential targets …

The adenosine homo, iso and heteroreceptor complexes in the basal ganglia play a highly
significant role in modulating the indirect and direct pathways and the striosomal projections …

Guanosine, a guanine-based purine nucleoside, has been described as a neuromodulator
that exerts neuroprotective effects in animal and cellular ischemia models. However …

In the striatum, adenosine A2A receptors (A2AR) are mainly expressed within the soma and
dendrites of the striatopallidal neuron. A predominant proportion of these striatal …

G protein-coupled receptors (GPCRs) have the propensity to form homo-and heterodimers.
Dysfunction of these dimers has been associated with multiple diseases, eg, pre-eclampsia …

Traumatic brain injury (TBI) is a leading cause of disability worldwide, triggering chronic
neurodegeneration underlying cognitive and mood disorder still without therapeutic …