Allosteric modulators of metabotropic glutamate 5 receptors (mGlu5 receptors) have been
identified as a promising treatment to independently alleviate both negative affective states …

Major depressive disorder (MDD) is one of the leading global causes of disability. Symptoms
of MDD can vary person to person, and current treatments often fail to alleviate the poor …

Early life adversity (ELA) is a risk factor for major depressive disorder (MDD), however the
underlying mechanisms are not well understood. Clinical studies suggest that negative …

Abstract Ginsenoside (GS Rg1), which has neuroprotection and anti-inflammation activities,
is the main active ingredient of Radix Ginseng. However, its antidepressant-like effect in rats …

Cognitive judgement bias tests have become important new tools for the assessment of
animal emotions. They allow for the inference of an animal's emotional state based on …

В обзоре представлен сравнительный анализ экспериментальных моделей
клинической депрессии. Проведена классификация по типу формирования …

Depressed individuals are biased to perceive, interpret, and judge ambiguous cues in a
negative/pessimistic manner. Depressed mood can induce and exacerbate these biases …

Affect-driven cognitive biases can be used as an indicator of affective (emotional) state.
Since humans in negative affective states demonstrate greater responses to negatively …

Judgement bias tasks are designed to provide markers of affective states. A recent study of
European starlings (Sturnus vulgaris) demonstrated modest familial effects on judgement …

Early life adversity (ELA) is a risk factor for major depressive disorder (MDD), however the
underlying mechanisms are not well understood. Clinical studies suggest that negative …