Heart Failure Society (JHFS). The working committee for this project includes members and
collaborators involved in the previous versions of the heart failure guidelines and members …

Multiple drug classes have shown incremental benefits in heart failure with reduced ejection
fraction. Most of these trials were designed to achieve specific doses of the investigational …

As new treatments continue to improve clinical outcomes in coronary artery disease (CAD)
and heart failure, it is necessary to characterize the appropriate use of β-adrenergic receptor …

Importance β-Blockers are prescribed to most patients with heart failure (HF) with a
preserved ejection fraction (HFpEF), but their effect on HFpEF remains unclear. Objective To …

Beta-blockers are the cornerstone of treatment for various cardiovascular conditions.
Although their effects have classically been considered to be driven by their antagonistic …

Heart failure (HF) and HF 30-day readmission rates have been a major focus of efforts to
reduce health care cost in the recent era. Since the implementation of the Affordable Care …

Background: Heart failure (HF) is a syndrome associated with exercise intolerance, and its
symptoms are more common in patients with low skeletal muscle mass (SMM). Estimation of …

Heart failure is a complex clinical syndrome involving a multitude of neurohormonal
pathways including the renin-angiotensin-aldosterone system, sympathetic nervous system …

Human G protein-coupled receptors (GPCRs), especially adrenoceptors, play a crucial role
in maintaining important physiological activities including cardiovascular and pulmonary …

Congestive heart failure is a final common clinical pathway for several diseases in
childhood, such as familial cardiomyopathy, viral myocarditis, inborn errors of metabolism …