Histone lysine acetylation is critical in regulating transcription. Dysregulation of this process
results in aberrant gene expression in various diseases, including cancer. The …

Epigenetic mechanisms, especially DNA methylation and histone modifications, are
dynamic processes that regulate the gene expression transcriptional program in normal and …

Infiltrating and tissue-resident myeloid cells are essential regulators of innate and adaptive
immunity. During inflammation, and in response to microbial products, these cells can adapt …

The bromodomain and extra-terminal domain (BET) family of proteins are readers which
specifically recognize histone-acetylated lysine residues. Each BET bromodomain protein …

Objective The aim of this study was to investigate the role of CD109 in rheumatoid arthritis
(RA) fibroblast-like synoviocytes (FLSs) and to evaluate its potential as a therapeutic target …

The tumor microenvironment (TME) is a complex ecosystem, including blood vessels,
immune cells, fibroblasts, extracellular matrix, cytokines, hormones, and so on. The TME …

BET bromodomain proteins are important epigenetic regulators of gene expression that bind
acetylated histone tails and regulate the formation of acetylation-dependent chromatin …

Protein-protein interactions (PPIs) cover a very wide range of biological functions and
consequently have become one of the favourite targets for new therapeutic strategies. PPIs …

Epigenetic agents such as bromodomain and extra‐terminal region inhibitors (BETi) slow
tumor growth via tumor intrinsic alterations; however, their effects on antitumor immunity …

Interleukin-17A (IL17A) plays a critical role in the development of numerous autoimmune
diseases, including psoriasis. The clinical success of IL17A neutralizing biologics in …