Dominant Noonan syndrome-causing LZTR1 mutations specifically affect the Kelch domain substrate-recognition surface and enhance RAS-MAPK signaling
M Motta, M Fidan, E Bellacchio… - Human molecular …, 2019 - academic.oup.com
Noonan syndrome (NS), the most common RASopathy, is caused by mutations affecting
signaling through RAS and the MAPK cascade. Recently, genome scanning has discovered …
signaling through RAS and the MAPK cascade. Recently, genome scanning has discovered …
Mutations in MAP3K1 that cause 46,XY disorders of sex development disrupt distinct structural domains in the protein
A Chamberlin, R Huether, AZ Machado… - Human molecular …, 2019 - academic.oup.com
Missense mutations in the gene, MAP3K1, are a common cause of 46, XY gonadal
dysgenesis, accounting for 15–20% of cases [Ostrer, 2014, Disorders of sex development …
dysgenesis, accounting for 15–20% of cases [Ostrer, 2014, Disorders of sex development …
SET domain containing protein 5 (SETD5) enhances tumor cell invasion and is associated with a poor prognosis in non-small cell lung cancer patients
H Yu, J Sun, C Zhao, H Wang, Y Liu, J Xiong, J Chang… - BMC cancer, 2019 - Springer
Background SET domain containing 5 (SETD5) is related to the aggressiveness of prostate
and mammary cancers, but its association with non-small cell lung cancer (NSCLC) is …
and mammary cancers, but its association with non-small cell lung cancer (NSCLC) is …
Nitration-induced ubiquitination and degradation control quality of ERK1
Y Zhang, X Huang, J Wang, X Wang, X Liu… - Biochemical …, 2019 - portlandpress.com
The mitogen-activated protein kinase ERK1/2 (ERKs, extracellular-regulated protein
kinases) plays important roles in a wide spectrum of cellular processes and have been …
kinases) plays important roles in a wide spectrum of cellular processes and have been …
Structural basis for renal cancer by the dynamics of pVHL-dependent JADE1 stabilization and β-catenin regulation
S Shafique, S Rashid - Progress in Biophysics and Molecular Biology, 2019 - Elsevier
Renal cancer is the major cause of mortality due to abnormal functioning of von Hippel-
Lindau (pVHL) and Jade Family PHD Finger 1 (JADE1) complex. E3 ubiquitin ligase JADE1 …
Lindau (pVHL) and Jade Family PHD Finger 1 (JADE1) complex. E3 ubiquitin ligase JADE1 …
Functional significance of the E3 ubiquitin ligases in disease and therapeutics
JT Dongdem, CA Wezena - Hydrolases, 2019 - books.google.com
E3 ubiquitin ligases of which there are> 600 putative in humans, constitute a family of highly
heterogeneous proteins and protein complexes that are the ultimate enzymes responsible …
heterogeneous proteins and protein complexes that are the ultimate enzymes responsible …
MGLU2/3 Receptor Agonist LY379268 on ERK and CREB Protein Expression and Phosphorylation: Analysis of Acute and Chronic Treatment of Rats
CB Aguilar - 2019 - search.proquest.com
This thesis addresses the question of what is the signaling pathway behind the metabotropic
glutamate (mGlu) receptors 2 and 3 and how acute or prolonged exposure to the agonist …
glutamate (mGlu) receptors 2 and 3 and how acute or prolonged exposure to the agonist …