JAK inhibitors for the treatment of autoimmune and inflammatory diseases

Y Jamilloux, T El Jammal, L Vuitton… - Autoimmunity …, 2019 - Elsevier
Cytokines play a central role in the pathophysiology of autoimmune and inflammatory
diseases. Several cytokines signal through the JAK-STAT pathway, which is now recognized …

Myeloid cells during viral infections and inflammation

AA Stegelmeier, JP van Vloten, RC Mould, EM Klafuric… - Viruses, 2019 - mdpi.com
Myeloid cells represent a diverse range of innate leukocytes that are crucial for mounting
successful immune responses against viruses. These cells are responsible for detecting …

Altered N‐glycosylation profiles as potential biomarkers and drug targets in diabetes

N Rudman, O Gornik, G Lauc - FEBS letters, 2019 - Wiley Online Library
N‐glycosylation is a ubiquitous protein modification, and N‐glycosylation profiles are
emerging as both biomarkers and functional effectors in various types of diabetes. Genome …

Immunological aspects of autoimmune thyroid disease–Complex interplay between cells and cytokines

J Luty, K Ruckemann-Dziurdzińska, JM Witkowski… - Cytokine, 2019 - Elsevier
Autoimmune thyroid disease (ATD) is a chronic autoimmune thyroiditis with a complex
pathogenesis including environmental factors, genetic background and immune system …

Interleukin gene polymorphisms in chronic periodontitis: A case-control study in the Indian population

P Majumder, SK Panda, S Ghosh, SK Dey - Archives of Oral Biology, 2019 - Elsevier
Objective The aim of the present study was to investigate the possible association between
seven Interleukin (IL) gene polymorphisms and their interaction with the chronic …

Cytokines: the yin and yang of vitiligo pathogenesis

M Singh, A Kotnis, SD Jadeja, A Mondal… - Expert review of …, 2019 - Taylor & Francis
Introduction: Dysregulation of melanocyte function is associated with vitiligo, an idiopathic
autoimmune hypopigmentary skin disorder, caused by the selective destruction of …

Multivariate genome-wide association analysis of a cytokine network reveals variants with widespread immune, haematological, and cardiometabolic pleiotropy

AP Nath, SC Ritchie, NF Grinberg, HHF Tang… - The American Journal of …, 2019 - cell.com
Cytokines are essential regulatory components of the immune system, and their aberrant
levels have been linked to many disease states. Despite increasing evidence that cytokines …

Dendritic cells aggregate inflammation in experimental osteoarthritis through a toll-like receptor (TLR)-dependent machinery response to challenges

F Nie, F Ding, B Chen, S Huang, Q Liu, C Xu - Life sciences, 2019 - Elsevier
Abstract Aims Dendritic cells (DCs) and Toll-like receptor (TLR) participate in mediating
inflammation process. However, the functional role of TLR expressed on DCs in …

Alteration of serum levels of cytokines in schizophrenic patients before and after treatment with risperidone

E Azizi, AZ Hosseini, S Soudi… - Iranian Journal of …, 2019 - publish.kne-publishing.com
Alteration of Serum Levels of Cytokines in Schizophrenic Patients before and after Treatment with
Risperidone Page 1 Copyright© June 2019, Iran J Allergy Asthma Immunol. All rights reserved …

A study of the immunoregulatory function of TLR3 and TLR4 on mesenchymal stem cells in ankylosing spondylitis

Y Li, L Huang, Z Cai, W Deng, P Wang… - Stem cells and …, 2019 - liebertpub.com
The pathogenesis of ankylosing spondylitis (AS), an immune-mediated inflammatory
disease, remains largely unknown. We previously reported that the immunoregulatory …