Additive manufacturing of photo-crosslinked gelatin scaffolds for adipose tissue engineering

L Tytgat, L Van Damme, J Van Hoorick, H Declercq… - Acta Biomaterialia, 2019 - Elsevier
There exists a clear clinical need for adipose tissue reconstruction strategies to repair soft
tissue defects which outperform the currently available approaches. In this respect, additive …

Extrusion-based 3D printing of photo-crosslinkable gelatin and κ-carrageenan hydrogel blends for adipose tissue regeneration

L Tytgat, L Van Damme, MPO Arevalo… - International journal of …, 2019 - Elsevier
Current soft tissue repair techniques for women with breast cancer remain associated with
several drawbacks including surgical complications and a high resorption rate for lipofilling …

Multifunctional pyrazoline based AIEgens: real-time tracking and specific protein “fishing” of lipid droplets

N Zhao, Y Li, W Yang, J Zhuang, Y Li, N Li - Chemical Science, 2019 - pubs.rsc.org
Despite the rapid development of organic fluorescent probes for bioimaging and biosensing
applications, construction of advanced probes with multiple biological functions by precisely …

Lack of monoacylglycerol lipase prevents hepatic steatosis by favoring lipid storage in adipose tissue and intestinal malabsorption [S]

M Tardelli, FV Bruschi, T Claudel, CD Fuchs… - Journal of Lipid …, 2019 - ASBMB
Monoacylglycerol lipase (MGL) is the rate-limiting enzyme in the degradation of
monoacylglycerols. To examine the role of MGL in hepatic steatosis, WT and MGL KO …

An AIEgen-based fluorescent probe for highly selective and specific imaging of lipid droplets in L02 and HepG2 cells

J Shi, Y Tian, B Guo, Y Wu, J Jing, R Zhang… - Sensors and Actuators B …, 2019 - Elsevier
Lipid droplets (LDs), as dynamic organelles, are associated with physiologically and
pathologically metabolic processes. Especially, in human liver cancer cells (HepG2 cells) …

Muscle xenografts reproduce key molecular features of facioscapulohumeral muscular dystrophy

AL Mueller, A O'Neill, TI Jones, A Llach, LA Rojas… - Experimental …, 2019 - Elsevier
Aberrant expression of DUX4, a gene unique to humans and primates, causes
Facioscapulohumeral Muscular Dystrophy-1 (FSHD), yet the pathogenic mechanism is …

Skeletal muscle fiber type-selective effects of acute exercise on insulin-stimulated glucose uptake in insulin-resistant, high-fat-fed rats

MW Pataky, CS Yu, Y Nie, EB Arias… - American Journal …, 2019 - journals.physiology.org
Insulin-stimulated glucose uptake (GU) by skeletal muscle is enhanced several hours after
acute exercise in rats with normal or reduced insulin sensitivity. Skeletal muscle is …

Novel two-photon fluorescent probe with high fluorescence quantum yields for tracking lipid droplets in biological systems

J Niu, Y Liu, W Wang, W Lin - Spectrochimica Acta Part A: Molecular and …, 2019 - Elsevier
Lipid droplets (LDs) played an important role in storing neutral lipids process. In this work,
we developed a series of fluorescent dyes PIE1-PIE4 with high fluorescence quantum yields …

[HTML][HTML] Peroxisomal gene and protein expression increase in response to a high-lipid challenge in human skeletal muscle

TY Huang, D Zheng, RC Hickner, JJ Brault… - Metabolism, 2019 - Elsevier
Peroxisomes are essential for lipid metabolism and disruption of liver peroxisomal function
results in neonatal death. Little is known about how peroxisomal content and activity …

CRISPR-Cas9-mediated knockout of SPRY2 in human hepatocytes leads to increased glucose uptake and lipid droplet accumulation

NL Cook, M Pjanic, AG Emmerich, AS Rao… - BMC Endocrine …, 2019 - Springer
Background The prevalence of obesity and its comorbidities, including type 2 diabetes
mellitus (T2DM), is dramatically increasing throughout the world; however, the underlying …