Gain-of-function mutant p53: all the roads lead to tumorigenesis

Y Stein, V Rotter, R Aloni-Grinstein - International journal of molecular …, 2019 - mdpi.com
The p53 protein is mutated in about 50% of human cancers. Aside from losing the tumor-
suppressive functions of the wild-type form, mutant p53 proteins often acquire inherent …

Molecular alterations in thyroid carcinoma

MRH Al Rasheed, B Xu - Surgical pathology clinics, 2019 - surgpath.theclinics.com
Thyroid carcinoma is the most common cancer in the endocrine system. Recent advances,
using next-generation sequencing, have shed light on the molecular pathogenesis of thyroid …

Oxidative stress in thyroid carcinomas: biological and clinical significance

RA El Hassani, C Buffet, S Leboulleux… - Endocrine-related …, 2019 - erc.bioscientifica.com
At physiological concentrations, reactive oxygen species (ROS), including superoxide
anions and H 2 O 2, are considered as second messengers that play key roles in cellular …

Genetic-guided risk assessment and management of thyroid cancer

M Xing - Endocrinology and Metabolism Clinics, 2019 - endo.theclinics.com
Thyroid cancer is a common endocrine malignancy, which histologically includes follicular
epithelial cell–derived thyroid cancer and parafollicular C-cell–derived medullary thyroid …

METTL7B promotes migration and invasion in thyroid cancer through epithelial-mesenchymal transition

D Ye, Y Jiang, Y Sun, Y Li, Y Cai… - Journal of …, 2019 - jme.bioscientifica.com
Thyroid cancer is associated with one of the most malignant endocrine tumors. However,
molecular mechanisms underlying thyroid tumorigenesis and progression remain unclear. In …

The significance of gene mutations across eight major cancer types

P Paul, AK Malakar, S Chakraborty - Mutation Research/Reviews in …, 2019 - Elsevier
Mutations occur spontaneously, which can be induced by either chemicals (eg benzene) or
biological factors (eg virus). Not all mutations cause noticeable changes in cellular functions …

E-cadherin expression is associated with susceptibility and clinicopathological characteristics of thyroid cancer: A PRISMA-compliant meta-analysis

C Zhou, C Yang, D Chong - Medicine, 2019 - journals.lww.com
Background: Recently, many studies have been carried out to investigate the
clinicopathological significance of E-cadherin expression in thyroid cancer. However, the …

[图书][B] Inherited disorders of the thyroid system

G Medeiros-Neto, JB Stanbury - 2019 - taylorfrancis.com
First Published in 1994, Inherited Disorders of the Thyroid System presents a thorough and
comprehensive study of the biology of varied thyroid disorders illustrated by numerous …

Coding molecular determinants of thyroid cancer development and progression

V Valvo, C Nucera - Endocrinology and Metabolism Clinics, 2019 - endo.theclinics.com
Thyroid cancer not only is the most common malignancy of the endocrine system but also
shows an increased incidence rate, 1 overall increasing 3% annually. 2 The incidence …

Genetic alterations in anaplastic thyroid carcinoma

M Rashid, A Agarwal, R Pradhan… - Indian Journal of …, 2019 - journals.lww.com
Results: A total of 34 patients were studied: Mean age 58.6+ 11.6 years with F: M-1.8: 1,
60% had history of goiter. Most common presenting symptom was rapidly growing thyroid …