Epigenetic alterations, along with genetic alterations, have long been regarded as the most
important mechanism participating in carcinogenesis. DNA methylation, histone …

Heat shock protein 90 (HSP90) molecular chaperones are a family of ubiquitous proteins
participating in several cellular functions through the regulation of folding and/or assembly of …

Thyroid cancer remains the highest prevailing endocrine malignancy, and its incidence rate
has progressively increased in the previous years. Above 95% of thyroid tumor are follicular …

Epigenetic therapy has been demonstrated to be a viable strategy for breast cancer
treatment. In this study, we report the anti-tumor activity of a hydroxamate-based histone …

Background: With an increasing understanding of the antitumor immune response,
considerable progress has been made in the field of tumor immunotherapy in the last …

It is evident that epigenetics plays an important role in gene regulation. Consequently, any
disruption in epigenetic memory will manifest into gene expression and lead to long …

Objectives To define ultrastructural features accompanying to antitumor effects of
gemcitabine, vinorelbine and cyclooxygenase inhibitors in C6 glioma cells in vitro …

Combination therapy of multiple drugs with different mechanisms can overcome drug
resistance, improve safety and efficacy, and thus becomes a promising strategy in cancer …

O cancro é uma doença comum à Medicina Veterinária e Humana e é uma das principais
causas de morte. Apesar das várias abordagens terapêuticas oncológicas existentes, a sua …

O cancro é uma doença comum à Medicina Veterinária e Humana e é uma das principais
causas de morte. Apesar das várias abordagens terapêuticas oncológicas existentes, a sua …