Apoptosis, an important form of programmed cell death (PCD), is a tightly regulated cellular
process to eliminate unwanted or damaged cells. Resistance of apoptosis is a hallmark of …

Inhibitors of apoptosis proteins (IAPs) inhibit caspase activity, allowing various cancers to
reduce programmed cell death (apoptosis) and resist drug treatment. The second …

One obstacle in de novo protein design is the vast sequence space that needs to be
searched through to obtain functional proteins. We developed a new method using structural …

In order to develop original water soluble antagonists of X‐linked inhibitor of apoptosis
protein (XIAP), a novel bicyclic scaffold was designed based on 8, 5‐fused bicyclic lactam …

Cancer is one of the leading causes of death in the world, arising when cells accumulate
genomic mutations that render them incapable of controlling their own proliferation and …