Differential aggregation and phosphorylation of alpha synuclein in membrane compartments associated with Parkinson disease

A Canerina-Amaro, D Pereda, M Diaz… - Frontiers in …, 2019 - frontiersin.org
The aggregation of α-synuclein (α-syn) is a major factor behind the onset of Parkinson's
disease (PD). Sublocalization of this protein may be relevant for the formation of multimeric α …

Neuroprotective effect of thiamine triethylorthoformate conjugate against Parkinson disease in a mouse model

Y Dong, Q Xu, X Jia, C Li, D Xu, Y Jiao - Tropical Journal of Pharmaceutical …, 2019 - ajol.info
Purpose: To investigate the effect of thiamine triethylorthoformate conjugate (TTO) on
Parkinson disease (PD) in vitro and in vivo in a mice model. Methods: The effect of TTO on …

Ih loss of function as a pathogenic mechanism underlying the selective vulnerability of nigral dopamine neurons in Parkinson's disease

C Carbone - 2019 - flore.unifi.it
Non-homogeneous degeneration within midbrain dopaminergic (DA) neurons is a
histopathological hallmark of Parkinson's disease (PD). Typically, DA neurons in the …

[引用][C] The locus coeruleus: Another vulnerability target in Parkinson's disease

WH Oertel, MT Henrich, A Janzen… - Movement …, 2019 - Wiley Online Library
The α-synucleinopathy Parkinson's disease (PD) affects, in addition to the dopaminergic
SNc, other vulnerable neurotransmitter systems in the central nervous system (CNS), for …