Homeobox (HOX) transcription factors, encoded by a subset of homeodomain superfamily
genes, play pivotal roles in many aspects of cellular physiology, embryonic development …

Prostate cancer is a heterogeneous disease, the second deadliest malignancy in men and
the most commonly diagnosed cancer among men. Traditional plants have been applied to …

To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-
genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence …

Oncogenesis is driven by germline, environmental and stochastic factors. It is unknown how
these interact to produce the molecular phenotypes of tumors. We therefore quantified the …

The mouse double minute 4 (MDM4) is emerging from the shadow of its more famous
relative MDM2 and is starting to steal the limelight, largely due to its therapeutic possibilities …

Background The relationship between first-degree family history of female breast cancer and
prostate cancer risk in the general population remains unclear. We performed a meta …

Prostate cancer is the second most common male cancer affecting Western society. Despite
substantial advances in the exploration of prostate cancer biomarkers and treatment …

Muscle bulk in adult healthy humans is highly variable even after height, age, and sex are
accounted for. Low muscle mass, due to fewer and/or smaller constituent muscle fibers …

Prostate cancer (PCa) remains the most common cancer in men. The proportion of all PCa
attributable to high-risk hereditary factors has been estimated to 5–15%. Recent landmark …

Genome-wide association studies (GWAS) have identified~ 170 genetic loci associated with
prostate cancer (PCa) risk, but most of them were identified in European populations. We …