Under steady-state conditions, bone marrow-derived immature myeloid cells (IMC)
differentiate into granulocytes, macrophages and dendritic cells (DCs). This differentiation is …

The tumor microenvironment (TME) is comprised of many different cell populations, such as
cancer-associated fibroblasts and various infiltrating immune cells, and non-cell …

Immunotherapies are the most rapidly growing drug class and have a major impact in
oncology and on human health. It is increasingly clear that the effectiveness of …

Purpose: Upregulation of programmed death-ligand 1 (PD-L1) on circulating and tumor-
infiltrating myeloid cells is a critical component of GBM-mediated immunosuppression that …

Therapies aimed at minimizing adverse remodeling in cardiovascular diseases on a
molecular and cellular basis are urgently needed. Exosomes are nanosized lipid vesicles …

Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of mononuclear and
polymorphonuclear myeloid cells, which are present at very low numbers in healthy …

The aging process is associated with chronic low-grade inflammation in both humans and
rodents, commonly called inflammaging. At the same time, there is a gradual decline in the …

Cancer immunotherapy has altered the management of human malignancies, improving
outcomes in an expanding list of diseases. Breast cancer-presumably due to its perceived …

In recent years, an increasing number of studies have shown that there is an important
connection between nitric oxide (NO) and the pathology of malignant diseases, but we are …

Phagocytes are cells of the immune system that play important roles in phagocytosis,
respiratory burst and degranulation—key components of innate immunity and response to …