In terrestrial vertebrates, bone tissue constitutes the 'osteoimmune'system, which functions
as a locomotor organ and a mineral reservoir as well as a primary lymphoid organ where …

There are over 1,000,000 publications on diet and health and over 480,000 references on
inflammation in the National Library of Medicine database. In addition, there have now been …

The regeneration of lost periodontal apparatus in periodontitis treatment remains a clinical
challenge due to the limited regenerative capacity of cementum, periodontal ligament and …

The term osteoimmunology was coined many years ago to describe the research field that
deals with the cross-regulation between bone cells and the immune system. As a matter of …

Osteosarcoma is a rare primary bone cancer characterized by cancer cells producing
calcified osteoid extracellular matrix and inducing lung metastases with a high frequency …

The regenerative medicine, a new discipline that merges biological sciences and the
fundamental of engineering to develop biological substitutes, has greatly benefited from …

Macrophages contribute to the pathogenesis of rheumatoid arthritis (RA). They can display
different states of activation or “polarization,” notably the so-called inflammatory “M1” and the …

Many older persons lose their mobility and independence due to multiple diseases
occurring simultaneously. Geroscience is aimed at developing innovative approaches to …

In the process of bone tissue engineering, the osteoimmunomodulatory property of
biomaterials is very important for osteogenic differentiation of stem cells, which determines …

Bone physiology relies on the delicate balance between resorption and formation of its
tissue. Bone resorption depends on a process called osteoclastogenesis in which bone …