Asthma is a chronic inflammatory airway disease associated with type 2 cytokines
interleukin-4 (IL-4), IL-5, and IL-13, which promote airway eosinophilia, mucus …

The recent Lancet commission has highlighted that “asthma” should be used to describe a
clinical syndrome of wheeze, breathlessness, chest tightness, and sometimes cough. The …

Eosinophilic gastroenteritis (EGE) is a digestive disorder in children and adults that is
characterized by eosinophilic infiltration in the stomach and intestine. The underlying …

Current management of severe asthma relying either on guidelines (bulk approach) or on
disease phenotypes (stratified approach) did not improve the burden of the disease. Several …

It is now well established that mast cells (MCs) play a crucial role in asthma. This is
supported by multiple lines of evidence, including both clinical studies and studies on MC …

Immunoglobulin E (IgE)-associated allergy is the most common immunologically-mediated
hypersensensitivity disease. It is based on the production of IgE antibodies and T cell …

Chronic obstructive pulmonary disease (COPD) is a significant cause of morbidity and
mortality worldwide. In contrast to other chronic diseases, COPD is increasing in prevalence …

Objectives To review the efficacy of anti-IgE therapy in allergic rhinitis (AR). Methods
Literature search was performed using the PubMed and Proquest Central databases at …

Omalizumab is a humanized monoclonal antibody which binds to human immunoglobulins
E (IgE), thus preventing their interactions with both high affinity and low affinity IgE receptors …

Background: Omalizumab may modulate airway remodeling in severe asthma. Using forced
expiratory volume in 1 second (FEV1) as a surrogate of airway remodeling, we aimed to …