Defining physiological normoxia for improved translation of cell physiology to animal models and humans
TP Keeley, GE Mann - Physiological reviews, 2019 - journals.physiology.org
The extensive oxygen gradient between the air we breathe (Po2~ 21 kPa) and its ultimate
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …
Skeletal muscle interstitial O2 pressures: bridging the gap between the capillary and myocyte
The oxygen transport pathway from air to mitochondria involves a series of transfer steps
within closely integrated systems (pulmonary, cardiovascular, and tissue metabolic). Small …
within closely integrated systems (pulmonary, cardiovascular, and tissue metabolic). Small …
More homogeneous capillary flow and oxygenation in deeper cortical layers correlate with increased oxygen extraction
Our understanding of how capillary blood flow and oxygen distribute across cortical layers to
meet the local metabolic demand is incomplete. We addressed this question by using two …
meet the local metabolic demand is incomplete. We addressed this question by using two …
Edward F. Adolph distinguished lecture. Contemporary model of muscle microcirculation: gateway to function and dysfunction
DC Poole - Journal of Applied Physiology, 2019 - journals.physiology.org
This review strikes at the very heart of how the microcirculation functions to facilitate blood-
tissue oxygen, substrate, and metabolite fluxes in skeletal muscle. Contemporary evidence …
tissue oxygen, substrate, and metabolite fluxes in skeletal muscle. Contemporary evidence …
Unaltered V̇o2 kinetics despite greater muscle oxygenation during heavy-intensity two-legged knee extension versus cycle exercise in humans
Relative perfusion of active muscles is greater during knee extension ergometry (KE) than
cycle ergometry (CE). This provides the opportunity to investigate the effects of increased O2 …
cycle ergometry (CE). This provides the opportunity to investigate the effects of increased O2 …
Exercise intolerance in patients with mitochondrial myopathies: perfusive and diffusive limitations in the O2 pathway
Highlights•Mitochondrial myopathies include various inherited diseases, deriving from
primary dysfunction of the mitochondrial respiratory chain and resulting predominantly in …
primary dysfunction of the mitochondrial respiratory chain and resulting predominantly in …
Skeletal muscle interstitial Po2 kinetics during recovery from contractions
The oxygen partial pressure in the interstitial space (Po2 is) drives O2 into the myocyte via
diffusion, thus supporting oxidative phosphorylation. Although crucial for metabolic recovery …
diffusion, thus supporting oxidative phosphorylation. Although crucial for metabolic recovery …
Mathematical modeling of blood flow in the eye
Mathematical models linking ocular mechanics, circulation, and oxygenation are needed to
improve the interpretation and prediction of key components of ocular health and disease …
improve the interpretation and prediction of key components of ocular health and disease …
Mini-review: Perfluorocarbons, oxygen transport, and microcirculation in low flow states: in vivo and in vitro studies
IP Torres Filho - Shock, 2019 - journals.lww.com
The in vivo study of microvascular oxygen transport requires accurate and challenging
measurements of several mass transfer parameters. Although recommended, blood flow …
measurements of several mass transfer parameters. Although recommended, blood flow …
Investigation of integrated effects of hydroxyapatite and VEGF on capillary morphogenesis of endothelial cells
Major drawbacks of using autografts and allografts for repairing large bone defects/injuries
are the shortage of available tissues and potential disease transmission. Bone tissue …
are the shortage of available tissues and potential disease transmission. Bone tissue …