Adult skeletal muscle can regenerate effectively after mild physical or chemical insult.
Muscle trauma or disease can overwhelm this innate capacity for regeneration and result in …

Laminin is a heterotrimeric glycoprotein with a key role in the formation and maintenance of
the basement membrane architecture and properties, as well as on the modulation of …

Skeletal muscle is inept in regenerating after traumatic injuries due to significant loss of
basal lamina and the resident satellite cells. To improve regeneration of skeletal muscle, we …

The healing of skeletal muscle injuries after major trauma or surgical reconstruction is often
complicated by the development of fibrosis leading to impaired function. Research in the …

Volumetric muscle loss (VML) is characterized by a critical loss of muscle tissue that is
accompanied by severe functional impairment and often long-term disability. Clinical …

Skeletal muscle has a remarkable regenerative capacity in response to mild injury.
However, when muscle is severely injured, muscle regeneration is impaired due to the loss …

This is a comprehensive overview of the epidemiology of each type of soft tissue defects and
the current successful applications of regenerative medicine and methods of advancing the …