Marine organisms' persistence hinges on the capacity for acclimatization and adaptation to
the myriad of interacting environmental stressors associated with global climate change. In …

Atherosclerosis, the principal cause of cardiovascular death worldwide, is a pathological
disease characterized by fibro-proliferation, chronic inflammation, lipid accumulation, and …

DNA N 4-methylcytosine (4mC) is one of the key epigenetic alterations, playing essential
roles in DNA replication, differentiation, cell cycle, and gene expression. To better …

DNA methylation, catalyzed by DNA methyltransferases (DNMTs), is an epigenetic mark that
needs to be faithfully replicated during mitosis in order to maintain cell phenotype during …

Underlying mechanisms of cardiovascular diseases (CVD) have been investigated for over
100 years and novel molecular level mechanisms in the pathophysiology are still …

The secreted frizzled-related protein 5 gene (SFRP5) that antagonize the Wnt/β-catenin
signaling is frequently inactivated by promoter methylation and oncogenic activation of the …

Lysine methylation, catalyzed by protein lysine methyltransferases (PKMTs), is a central post-
translational modification regulating many signaling pathways. It has direct and indirect …

A healthy diet improves life expectancy and helps to prevent common chronic diseases such
as type 2 diabetes (T2D) and obesity. The mechanisms driving these effects are not fully …

The human population is getting ageing. Both ageing and age-related diseases are
correlated with an increased number of senescent cells in the organism. Senescent cells do …

Lead (Pb) exposure during different stages of development has demonstrated dose,
duration, sex, and tissue-specific pathophysiological outcomes due to altered epigenetic …