Tumor cells must generate sufficient ATP and biosynthetic precursors in order to maintain
cell proliferation requirements. Otto Warburg showed that tumor cells uptake high amounts …

The tumor microenvironment (TME) is comprised of many different cell populations, such as
cancer-associated fibroblasts and various infiltrating immune cells, and non-cell …

Translocase of outer mitochondrial membrane 20 (TOMM20) plays an essential role as a
receptor for proteins targeted to mitochondria. TOMM20 was shown to be overexpressed in …

LncRNA CASC11 is a recently identified oncogenic lncRNA in colorectal cancer. This study
aimed to investigate the role of lncRNA CASC11 in small cell lung cancer (SCLC). In the …

Cancer cells have an unusual regulation of hydrogen ion dynamics that are driven by poor
vascularity perfusion, regional hypoxia, and increased glycolysis. All these forces …

Head and neck squamous cell carcinoma (HNSCC) is comprised of metabolically linked
distinct compartments. Cancer-associated fibroblasts (CAF) and nonproliferative carcinoma …

Background: Alternative splicing events have been increasingly reported for anomalous
perturbations in various cancers, including papillary thyroid cancer (PTC). Methods …

Mitochondria are dynamically regulated by fission and fusion processes. Silibinin induces
apoptosis of MCF-7 and MDA-MB-231 human breast cancer cells. However, whether or not …

Mitochondria are critical for cellular survival, and for their proper functioning, translocation
of∼ 1500 proteins across the mitochondrial membranes is required. The translocase of the …

Pancreatic ductal adenocarcinoma (PDAC) is commonly diagnosed when liver metastases
already emerged. We recently demonstrated that hepatic stromal cells determine the …