Searching for physiologically relevant in vitro dissolution techniques for orally inhaled drugs
S Radivojev, S Zellnitz, A Paudel, E Froehlich - International journal of …, 2019 - Elsevier
Inhalation is the preferred route for the treatment of lung diseases. More recently, also
formulations for systemic treatment have been developed. For efficient development of …
formulations for systemic treatment have been developed. For efficient development of …
[HTML][HTML] In vitro investigation on the impact of airway mucus on drug dissolution and absorption at the air-epithelium interface in the lungs
E Cingolani, S Alqahtani, RC Sadler, D Prime… - European Journal of …, 2019 - Elsevier
Although the mucus layer is the first biological barrier encountered by inhaled drugs upon
their deposition in the upper airways, its potential impact on drug dissolution and absorption …
their deposition in the upper airways, its potential impact on drug dissolution and absorption …
Pulmonary dissolution of poorly soluble compounds studied in an ex vivo rat lung model
Many inhaled drugs are poorly water soluble, and the dissolution rate is often the rate-
limiting step in the overall absorption process. To improve understanding of pulmonary drug …
limiting step in the overall absorption process. To improve understanding of pulmonary drug …
Effect of particle deposition density of dry powders on the results produced by an in vitro test system simulating dissolution-and absorption rates in the lungs
M Malmlöf, M Nowenwik, K Meelich, I Rådberg… - European Journal of …, 2019 - Elsevier
The surface area of the air/liquid interface in the lungs is substantial, so deposited doses of
aerosol medicines per interface surface area when administered via the inhalation route is …
aerosol medicines per interface surface area when administered via the inhalation route is …
Optimization of budesonide-loaded large-porous microparticles for inhalation using quality by design approach
L Zhang, X Zhang, J Li, M Beck-Broichsitter… - Journal of Drug Delivery …, 2019 - Elsevier
The aim of this study was to apply a quality by design (QbD) approach for the development
of budesonide (BUD)-loaded large porous microparticles (LPPs) for inhalation purpose. An …
of budesonide (BUD)-loaded large porous microparticles (LPPs) for inhalation purpose. An …
Insights into DPI sensitivity to humidity: An integrated in-vitro-in-silico risk-assessment
S Radivojev, JT Pinto, E Fröhlich, A Paudel - Journal of Drug Delivery …, 2019 - Elsevier
Dry powder inhalers (DPIs) are known to be sensitive to humidity. Erroneous storage of
these products by patients in high humidity environments, could present a potential risk …
these products by patients in high humidity environments, could present a potential risk …
Respirable aerosol exposures of nicotine dry powder formulations to in vitro, ex vivo, and in vivo pre-clinical models demonstrate consistency of pharmacokinetic …
D Sciuscio, J Hoeng, MC Peitsch… - Inhalation …, 2019 - Taylor & Francis
Background: Nicotine, because of its volatility, has a complex dosimetry following inhalation
as a vapor/aerosol mix. To better control the dosimetry, nicotine could be formulated with a …
as a vapor/aerosol mix. To better control the dosimetry, nicotine could be formulated with a …
[PDF][PDF] Ranking in vitro dissolution of orally inhaled drug substance powders in a time-efficient manner
RANKING IN VITRO DISSOLUTION OF ORALLY INHALED DRUG SUBSTANCE POWDERS IN
A TIME-EFFICIENT MANNER Page 1 RANKING IN VITRO DISSOLUTION OF ORALLY …
A TIME-EFFICIENT MANNER Page 1 RANKING IN VITRO DISSOLUTION OF ORALLY …