Biological aging is an inevitable and independent risk factor for a wide array of chronic
diseases including cardiovascular and metabolic diseases. Ample evidence has established …

A large body of evidence indicates that mitochondrial dysfunction has a major role in the
pathogenesis of multiple cardiovascular disorders. Over the past 2 decades, extraordinary …

Metabolism describes the life-sustaining chemical reactions in organisms that provide both
energy and building blocks for cellular survival and proliferation. Dysregulated metabolism …

Melatonin is a ubiquitous hormone found in various organisms and highly affects the
function of immune cells. In this review, we summarize the current understanding of the …

Mitochondrial dysfunction is now recognized as a contributing factor to the early pathology of
multiple human conditions including neurodegenerative diseases. Mitochondria are …

Pancreatic ductal adenocarcinoma (PDAC) requires mitochondrial oxidative
phosphorylation (OXPHOS) to fuel its growth; however, broadly inhibiting this pathway might …

Mitochondrial dynamics shape the mitochondrial network and contribute to mitochondrial
function and quality control. Mitochondrial fusion and division are integrated into diverse …

The purpose of this article is to highlight the role of dynamin-related protein 1 (Drp1) in
abnormal mitochondrial dynamics, mitochondrial fragmentation, autophagy/mitophagy, and …

The purpose of our study was to better understand the effects of mitochondrial-division
inhibitor 1 (Mdivi-1) on mitochondrial fission, mitochondrial biogenesis, electron transport …

Mitophagy, by maintaining mitochondrial quality control, plays a key role in maintaining
kidney function and is impaired in pathologic states. Macrophages are well known for their …