Endothelium structure and function in kidney health and disease
N Jourde-Chiche, F Fakhouri, L Dou, J Bellien… - Nature Reviews …, 2019 - nature.com
The kidney harbours different types of endothelia, each with specific structural and functional
characteristics. The glomerular endothelium, which is highly fenestrated and covered by a …
characteristics. The glomerular endothelium, which is highly fenestrated and covered by a …
Genomics of disease risk in globally diverse populations
Risk of disease is multifactorial and can be shaped by socio-economic, demographic,
cultural, environmental and genetic factors. Our understanding of the genetic determinants …
cultural, environmental and genetic factors. Our understanding of the genetic determinants …
Comparative genetic architectures of schizophrenia in East Asian and European populations
Schizophrenia is a debilitating psychiatric disorder with approximately 1% lifetime risk
globally. Large-scale schizophrenia genetic studies have reported primarily on European …
globally. Large-scale schizophrenia genetic studies have reported primarily on European …
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals
In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure
to identify genes, tissues, phenomes and medication contexts of blood pressure …
to identify genes, tissues, phenomes and medication contexts of blood pressure …
Improving the accuracy of two-sample summary-data Mendelian randomization: moving beyond the NOME assumption
J Bowden, F Del Greco M, C Minelli… - International journal …, 2019 - academic.oup.com
Background Two-sample summary-data Mendelian randomization (MR) incorporating
multiple genetic variants within a meta-analysis framework is a popular technique for …
multiple genetic variants within a meta-analysis framework is a popular technique for …
70-year legacy of the Framingham Heart Study
Abstract The Framingham Heart Study (FHS) was established in 1948 to improve
understanding of the epidemiology of coronary heart disease (CHD) in the USA. In 1961 …
understanding of the epidemiology of coronary heart disease (CHD) in the USA. In 1961 …
[HTML][HTML] Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates
Sleep is an essential state of decreased activity and alertness but molecular factors
regulating sleep duration remain unknown. Through genome-wide association analysis in …
regulating sleep duration remain unknown. Through genome-wide association analysis in …
[HTML][HTML] Genome-wide association study of body fat distribution identifies adiposity loci and sex-specific genetic effects
M Rask-Andersen, T Karlsson, WE Ek… - Nature …, 2019 - nature.com
Body mass and body fat composition are of clinical interest due to their links to
cardiovascular-and metabolic diseases. Fat stored in the trunk has been suggested to be …
cardiovascular-and metabolic diseases. Fat stored in the trunk has been suggested to be …
Type 2 diabetes and hypertension: a study on bidirectional causality
Rationale: In observational studies, type 2 diabetes mellitus (T2D) has been associated with
an increased risk of hypertension, and vice versa; however, the causality between these …
an increased risk of hypertension, and vice versa; however, the causality between these …
Association of genetic variants related to combined exposure to lower low-density lipoproteins and lower systolic blood pressure with lifetime risk of cardiovascular …
BA Ference, DL Bhatt, AL Catapano, CJ Packard… - Jama, 2019 - jamanetwork.com
Importance The relationship between exposure to lower low-density lipoprotein cholesterol
(LDL-C) and lower systolic blood pressure (SBP) with the risk of cardiovascular disease has …
(LDL-C) and lower systolic blood pressure (SBP) with the risk of cardiovascular disease has …