Poorly water-soluble drugs continue to be a problematic, yet important class of
pharmaceutical compounds for treatment of a wide range of diseases. Their prevalence in …

Oral administration is the most common route of drug delivery. The absorption of a drug from
the gut into the bloodstream involves disintegration of the solid dosage form, dissolution of …

Developing a mechanistic understanding of the impact of food structure and composition on
human health has increasingly involved simulating digestion in the upper gastrointestinal …

The availability of in vitro tools that are constructed on the basis of a detailed knowledge of
key aspects of gastrointestinal (GI) physiology and their impact on formulation performance …

During the past two decades, a range of in vitro models simulating the digestion processes
occurring in the stomach and small intestine have been developed to characterize lipid …

Purpose The use of three-dimensional printing (3DP) in the development of pharmaceutical
dosage forms is growing rapidly. However, the research is almost exclusively focussed on …

Self-dispersing lipid-based formulations, particularly self-microemulsifying drug delivery
systems (SMEDDS) have gained an increased interest in recent times as a means to …

The lipids and some surfactants present in oral lipid-based drug delivery systems are
potential substrates for the various lipases involved in gastrointestinal (GI) lipolysis. The …

Lipid-based formulations (LBFs) are a delivery strategy to enhance intestinal absorption of
poorly water-soluble drugs. LBF performance is typically evaluated by in vitro lipolysis …

Lipid-based formulations, including self-emulsifying drug delivery systems (SEDDS), are an
interesting formulation technology that enables the clinical use of compounds for which a …