Background: Obsessive-compulsive disorder (OCD) is associated with affective and
cognitive symptoms causing personal distress and reduced global functioning. These have …

Migraine is the most disabling and expensive chronic disorders, the etiology of which is still
not fully known. The neuronal systems,(glutammatergic, dopaminergic, serotoninergic and …

Eliglustat is a first‐line oral therapy for adults with Gaucher disease type 1 (GD1) and poor,
intermediate or extensive CYP2D6‐metabolizer phenotypes (> 90% of patients). We report …

Individuals carrying genetic variants that result in non-extensive CYP2D6 and CYP2C19
enzyme activity seem to be more prone to non-response and side-effects of psychotropic …

Background Eliglustat is a first-line oral treatment for adults with Gaucher disease type 1
who have an extensive, intermediate or poor CYP2D6 metabolizer phenotype (> 90% of …

This study aims to explore the potential benefits of antidepressant drugs related to metabolic
enzyme and drug-targeted genes, identify the optimal treatment of major depression, and …

Objective This study aims to determine the structure and frequency of haplotypes containing
either rs5758550 or rs16947, or both, together with other relevant CYP2D6 alleles …

Cytochrome P450 enzyme variant alleles have shown evidence that functional
consequences differ between substrates. A systematic effort has not yet been made to …

Aim: This study assesses the technical performance and cost of a targeted next-generation
sequencing (NGS) multigene pharmacogenetic (PGx) test. Materials & methods: A genetic …

Introducción. El citocromo CYP2C9 metaboliza, aproximadamente, el 15% de los fármacos
prescritos. Su gen presenta alelos cuyas frecuencias difieren entre grupos étnicos y …