Autoimmune diseases are characterized by the body's own immune system attack to the self-
tissues, a condition enabled, in predisposed subjects, by the reduction of self-tolerance. A …

It has been long realized that the immune and skeletal systems are closely linked. This
crosstalk, also known as osteoimmunology, is a primary process required for bone health …

In our previous study, we explored the therapeutic effect of berberine (BBR) against IL-21/IL-
21R mediated inflammatory proliferation of adjuvant-induced arthritic fibroblast-like …

Background and Purpose Celastrol exhibits anti‐arthritic effects in rheumatoid arthritis (RA),
but the role of celastrol‐mediated Ca2+ mobilization in treatment of RA remains undefined …

Rheumatic and musculoskeletal diseases are a heterogeneous group of disorders affecting
joint tissues and in some cases even organs, some of them being among the most common …

Rheumatoid arthritis (RA) is a systemic chronic autoimmune disease manifested by joint
destruction and deformity, hence decreasing patient's life quality. The aim of the present …

Rheumatoid arthritis (RA) is a multifactorial disease which is complicated by apoptosis
resistance. Autophagy is one of the key mechanisms which are involved in the development …

Reactive oxygen species (ROS) are implicated to play a role in initiating rheumatoid arthritis
(RA) pathogenesis. We have investigated the mechanism (s) by which essential redox …

Autophagy, a highly conserved and multistep lysosomal degradation process, plays a
pivotal role in maintaining cellular and physiological homeostasis. Of note, autophagy …

Autophagy is a lysosomal degradation mechanism with a crucial role in cell homeostasis
and in stress conditions. Because autophagy was found to be dysregulated in several …