The role of neuronal NLRP1 inflammasome in Alzheimer's disease: bringing neurons into the neuroinflammation game
The innate immune system and inflammatory response in the brain have critical impacts on
the pathogenesis of many neurodegenerative diseases including Alzheimer's disease (AD) …
the pathogenesis of many neurodegenerative diseases including Alzheimer's disease (AD) …
The evolving role of TRAFs in mediating inflammatory responses
B Dhillon, F Aleithan, Z Abdul-Sater… - Frontiers in …, 2019 - frontiersin.org
TRAFs [tumor necrosis factor (TNF) receptor associated factors] are a family of signaling
molecules that function downstream of multiple receptor signaling pathways and play a …
molecules that function downstream of multiple receptor signaling pathways and play a …
Association of urinary oxalate excretion with the risk of chronic kidney disease progression
Importance Oxalate is a potentially toxic terminal metabolite that is eliminated primarily by
the kidneys. Oxalate nephropathy is a well-known complication of rare genetic disorders and …
the kidneys. Oxalate nephropathy is a well-known complication of rare genetic disorders and …
Heat shock proteins and inflammasomes
Heat shock proteins (HSP) regulate inflammation in many physiological contexts. However,
inflammation is a broad process, involving numerous cytokines produced by different …
inflammation is a broad process, involving numerous cytokines produced by different …
The interplay between pattern recognition receptors and autophagy in inflammation
Y Zhu, J Deng, ML Nan, J Zhang, A Okekunle… - Autophagy Regulation of …, 2019 - Springer
Pattern recognition receptors (PRRs) are sensors of exogenous and endogenous “danger”
signals from pathogen-associated molecular patterns (PAMPs), and damage associated …
signals from pathogen-associated molecular patterns (PAMPs), and damage associated …
PKR-dependent cytosolic cGAS foci are necessary for intracellular DNA sensing
S Hu, H Sun, L Yin, J Li, S Mei, F Xu, C Wu, X Liu… - Science …, 2019 - science.org
Cyclic GMP-AMP synthase (cGAS) is a major sensor of cytosolic DNA from invading
pathogens and damaged cellular organelles. Activation of cGAS promotes liquid-like phase …
pathogens and damaged cellular organelles. Activation of cGAS promotes liquid-like phase …
Induction of neuroinflammation and neurotoxicity by synthetic hemozoin
R Velagapudi, AM Kosoko, OA Olajide - Cellular and molecular …, 2019 - Springer
Hemozoin produced by Plasmodium falciparum during malaria infection has been linked to
the neurological dysfunction in cerebral malaria. In this study, we determined whether a …
the neurological dysfunction in cerebral malaria. In this study, we determined whether a …
Antidepressant-like effects of agmatine and NOS inhibitors in chronic unpredictable mild stress model of depression in rats: the involvement of NLRP inflammasomes
Innate immunity activation in the central nervous system (CNS) is known to contribute to the
development of depression through NOD-like receptors containing pyrin domain 3 (NLRP3) …
development of depression through NOD-like receptors containing pyrin domain 3 (NLRP3) …
Mechanisms of Inflammasome Signaling, microRNA Induction and Resolution of Inflammation by Helicobacter pylori
SK Pachathundikandi, N Blaser, S Backert - Molecular Mechanisms of …, 2019 - Springer
Inflammasome-controlled transcription and subsequent cleavage-mediated activation of
mature IL-1β and IL-18 cytokines exemplify a crucial innate immune mechanism to combat …
mature IL-1β and IL-18 cytokines exemplify a crucial innate immune mechanism to combat …
In vivo evidence of inflammasome activation during spontaneous labor at term
Objective: Upon inflammasome activation, the adaptor protein of the inflammasome ASC
(apoptosis-associated speck-like protein containing a CARD) forms intracellular specks …
(apoptosis-associated speck-like protein containing a CARD) forms intracellular specks …