RAS has long been viewed as undruggable due to its lack of deep pockets for binding of
small molecule inhibitors. However, recent successes in the development of direct RAS …

Hutchinson-Gilford progeria syndrome (HGPS) is characterized by clinical features that
typically develop in childhood and resemble some features of accelerated aging. Children …

Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disorder caused by
progerin, a mutant lamin A variant. HGPS patients display accelerated aging and die …

Vascular stiffness is a major cause of cardiovascular disease during normal aging and in
Hutchinson–Gilford progeria syndrome (HGPS), a rare genetic disorder caused by …

Aging is an inevitable consequence of human life resulting in a gradual deterioration of cell,
tissue and organismal function and an increased risk to develop chronic ailments …

Pyrophosphate deficiency may explain the excessive vascular calcification found in children
with Hutchinson–Gilford progeria syndrome (HGPS) and in a mouse model of this disease …

Hutchinson-Gilford progeria syndrome (HGPS) is one of the most severe disorders among
laminopathies—a heterogeneous group of genetic diseases with a molecular background …

Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare genetic disorder for
which no cure exists. The disease is characterized by premature aging and inevitable death …

Hutchinson–Gilford progeria syndrome (HGPS) is characterized by accelerated senescence
due to a de novo mutation in the LMNA gene. The mutation produces an abnormal lamin A …

We begin this chapter by describing normal characteristics of several pertinent connective
tissue components, and some of the basic changes they undergo with ageing. These …