Modification of DNA with reactive groups and their post-synthetic transformations are useful
for labelling, imaging, bioconjugations and cross-linking with other (bio) molecules. This …

Click chemistry is applied to selectively modify, lable and ligate peptides for their use as
therapeutics, in biomaterials or analytical investigations. The inverse electron demand Diels …

We report the use of bioorthogonal reactions as an original strategy in photodynamic
therapy to achieve conditional phototoxicity and specific subcellular localization …

Two different and small functions for inverse electron demand Diels–Alder reactions were
applied for dual labeling of DNA: the 1, 2, 4-triazine was attached to the 5-position of 2 …

The replication of a virus within its host cell involves numerous interactions between viral
and cellular factors, which have to be tightly controlled in space and time. The intricate …

Metabolic incorporation of bioorthogonal functional groups into chromatin, followed by
copper-free conjugation reactions, often gives low yields due to steric hindrance. Here we …

We constructed a library of diarylsydnone (DASyd) candidates in search of a photoclickable
reaction toward alkynes, enabling an ultra-accelerated reactivity, while suppressing the …

In the present study, we used a nucleoside derivative 5-vinyluridine (VrU) for labeling during
cell division and for tumor imaging in living mice. We demonstrated that the functional …

We discovered N‐pyrrolyl alanine derivatives as efficient reagents for the fast and selective
Pictet–Spengler reaction with aldehyde‐containing biomolecules. Other aldehyde‐labeling …

Wir berichten über die Verwendung von bioorthogonalen Reaktionen als innovative
Strategie in der photodynamischen Therapie, um gleichzeitig eine gezielte Phototoxizität …