[HTML][HTML] The role of non-coding RNAs in oncology
FJ Slack, AM Chinnaiyan - Cell, 2019 - cell.com
For decades, research into cancer biology focused on the involvement of protein-coding
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …
[HTML][HTML] The evolution of long noncoding RNA acceptance in prostate cancer initiation, progression, and its clinical utility in disease management
VR Ramnarine, M Kobelev, EA Gibb, M Nouri, D Lin… - European urology, 2019 - Elsevier
Context It is increasingly evident that non–protein-coding regions of the genome can give
rise to transcripts that form functional layers of the cancer genome. One of most abundant …
rise to transcripts that form functional layers of the cancer genome. One of most abundant …
LncRNA PCAT1 activates AKT and NF-κB signaling in castration-resistant prostate cancer by regulating the PHLPP/FKBP51/IKKα complex
Z Shang, J Yu, L Sun, J Tian, S Zhu… - Nucleic acids …, 2019 - academic.oup.com
In PTEN-deficient prostate cancers, AKT signaling may be activated upon suppression of
androgen receptor signaling. Activation of AKT as well as NF-κB signaling involves a key …
androgen receptor signaling. Activation of AKT as well as NF-κB signaling involves a key …
[HTML][HTML] Dynamic recruitment of single RNAs to processing bodies depends on RNA functionality
Cellular RNAs often colocalize with cytoplasmic, membrane-less ribonucleoprotein (RNP)
granules enriched for RNA-processing enzymes, termed processing bodies (PBs). Here we …
granules enriched for RNA-processing enzymes, termed processing bodies (PBs). Here we …
[HTML][HTML] A long noncoding RNA distributed in both nucleus and cytoplasm operates in the PYCARD-regulated apoptosis by coordinating the epigenetic and …
H Miao, L Wang, H Zhan, J Dai, Y Chang, F Wu… - PLoS …, 2019 - journals.plos.org
Long noncoding RNAs (lncRNAs) participate in various biological processes such as
apoptosis. The function of lncRNAs is closely correlated with their localization within the cell …
apoptosis. The function of lncRNAs is closely correlated with their localization within the cell …
Long non-coding RNAs in genitourinary malignancies: a whole new world
Long non-coding RNAs (lncRNAs) are regulators of cellular machinery that are commonly
dysregulated in genitourinary malignancies. Accordingly, the investigation of lncRNAs is …
dysregulated in genitourinary malignancies. Accordingly, the investigation of lncRNAs is …
Long non-coding RNAs in prostate cancer: Functional roles and clinical implications
YH Xu, JL Deng, G Wang, YS Zhu - Cancer letters, 2019 - Elsevier
Long noncoding RNAs (lncRNAs) are defined as RNA transcripts longer than 200
nucleotides that do not encode proteins. LncRNAs have been documented to exhibit …
nucleotides that do not encode proteins. LncRNAs have been documented to exhibit …
[HTML][HTML] A novel AR translational regulator lncRNA LBCS inhibits castration resistance of prostate cancer
P Gu, X Chen, R Xie, W Xie, L Huang, W Dong, J Han… - Molecular cancer, 2019 - Springer
Background Progression to a castration resistance state is the main cause of deaths in
prostate cancer (PCa) patients. Androgen Receptor (AR) signaling plays the central role in …
prostate cancer (PCa) patients. Androgen Receptor (AR) signaling plays the central role in …
Retracted: LncRNA MALAT1 increases the stemness of gastric cancer cells via enhancing SOX2 mRNA stability
Y Xiao, J Pan, Q Geng, G Wang - FEBS Open Bio, 2019 - Wiley Online Library
Gastric cancer is one of the most common malignancies globally; cancer stem cells (CSC s)
are regarded as being at the root of tumor progression, and there is thus a need to identify …
are regarded as being at the root of tumor progression, and there is thus a need to identify …
[HTML][HTML] LncRNA MALAT1 acts as a miR-125a-3p sponge to regulate FOXM1 expression and promote hepatocellular carcinoma progression
S Liu, J Qiu, G He, Y Liang, L Wang, C Liu… - Journal of …, 2019 - ncbi.nlm.nih.gov
Background: Hepatocellular carcinoma (HCC) is a prominent cancer type, with long non-
coding RNAs (lncRNAs) being known to be relevant to its progression. We therefore …
coding RNAs (lncRNAs) being known to be relevant to its progression. We therefore …