The initial discovery that ob/ob mice become obese because of a recessive mutation of the
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …

Leptin resistance refers to states in which leptin fails to promote its anticipated effects,
frequently coexisting with hyperleptinaemia. Leptin resistance is closely associated with …

Hepatic steatosis develops when lipid influx and production exceed the liver's ability to
utilize/export triglycerides. Obesity promotes steatosis and is characterized by leptin …

Obesity is a pandemic disease affecting around 15% of the global population. Obesity is a
major risk factor for other conditions, such as type 2 diabetes and cardiovascular diseases …

Brown adipose tissue (BAT) is proposed to maintain thermal homeostasis through
dissipation of chemical energy as heat by the uncoupling proteins (UCPs) present in their …

Objective Polycystic ovary syndrome (PCOS) is associated with increased obesity with a
greater propensity to weight gain and a lack of sustainable lifestyle interventions. Altered …

Insulin action in the hypothalamus results in the suppression of hepatic glucose production
(HGP). Obesity is often associated with a diminished response to insulin, leading to impaired …

Animal studies have shown that leptin mediates the association between obesity and
hypertension. However, only a few studies have assessed this relationship in population …

Abstract Background and Objective: Hyperleptinemia is supposed to play a causal role in
the development of obesity-associated hypertension, possibly via increased sympathetic …

Background: Obesity is associated with reduced physiological responses to leptin and
insulin, leading to the concept of obesity-associated hormonal resistance. Objectives: Here …