The epithelial-mesenchymal transition (EMT) comprises an essential biological process
involving cancer progression as well as initiation. While the EMT has been regarded as a …

Transforming growth factor (TGF)-β is a secreted multifunctional cytokine that signals via
plasma membrane TGF-β type I and type II receptors and intercellular SMAD transcriptional …

METHODS: The combination of galunisertib and sorafenib (400 mg BID) was tested in
patients with advanced HCC and Child-Pugh A liver function without prior systemic therapy …

Prostate cancer (PC) progressed to castration resistance (CRPC) is a fatal disease. CRPC
tumors develop resistance to new-generation antiandrogen enzalutamide through lineage …

A high intratumoral frequency of neutrophils is associated with poor clinical outcome in most
cancer entities. It is hypothesized that immunosuppressive MDSC (myeloid-derived …

Abstract Background and Aims We assessed the activity of galunisertib, a small molecule
inhibitor of the transforming growth factor beta (TGF‐β1) receptor I, in second‐line patients …

Radiation therapy has been used for many years to treat tumors based on its DNA-damage-
mediated ability to kill cells. More recently, RT has been shown to exert beneficial …

Therapeutic attempts to treat hepatocellular carcinoma (HCC) frequently result in a poor
response or treatment failure. The efficacy of approved drugs and survival expectancies is …

Abstract 'First-generation'immune checkpoint inhibitors targeting Cytotoxic T-Lymphocyte
Antigen 4 (CTLA4) and Programmed death-ligand 1 (PD (L) 1) have undoubtedly …

Excessive vascular smooth muscle cell (SMC) proliferation, migration and extracellular
matrix (ECM) synthesis are key events in the development of intimal hyperplasia, a …