Genetic and pharmacological intervention studies have identified evolutionarily conserved
and functionally interconnected networks of cellular energy homeostasis, nutrient-sensing …

Precise genetic and epigenetic spatiotemporal regulation of gene expression is critical for
proper brain development, function and circuitry formation in the mammalian central nervous …

New neurons arise from quiescent adult neural progenitors throughout life in specific
regions of the mammalian brain. Little is known about the embryonic origin and …

Life experience can leave lasting marks, such as epigenetic changes, in the brain. How life
experience is translated into storable epigenetic information remains largely unknown. With …

Stress has pronounced effects on the brain, and thus behavioral outputs. This is particularly
true when the stress occurs during vulnerable points in development. A review of the clinical …

Background MeCP2—a chromatin-binding protein associated with Rett syndrome—has two
main isoforms, MeCP2-E1 and MeCP2-E2, differing in a few N-terminal amino acid residues …

Autism spectrum disorders (ASD) are hypothesized to originate in utero from perturbations in
neural stem cell niche regions of the developing brain. Dynamic epigenetic processes …

The approximately three times higher rate of migraine prevalence in women than men may
result from the mitochondrial transmission of this disease. Studies with imaging techniques …

Lead (Pb) exposure is associated with a wide range of neurological deficits. Environmental
exposures may impact epigenetic changes, such as DNA methylation, and can affect …

Females and males display differences in neural activity patterns, behavioral responses,
and incidence of psychiatric and neurological diseases. Sex differences in the brain appear …