The microbiome, cancer, and cancer therapy
BA Helmink, MAW Khan, A Hermann… - Nature medicine, 2019 - nature.com
With the advent of next-generation sequencing, we have an unprecedented ability to study
tumor and host genomes as well as those of the vast array of microorganisms that exist …
tumor and host genomes as well as those of the vast array of microorganisms that exist …
Modulating the microbiome to improve therapeutic response in cancer
JL McQuade, CR Daniel, BA Helmink… - The Lancet …, 2019 - thelancet.com
Although novel therapies, including immunotherapy, have dramatically improved outcomes
for many patients with cancer, overall outcomes are heterogeneous and existing biomarkers …
for many patients with cancer, overall outcomes are heterogeneous and existing biomarkers …
[HTML][HTML] Pain regulation by gut microbiota: molecular mechanisms and therapeutic potential
The relationship between gut microbiota and neurological diseases, including chronic pain,
has received increasing attention. The gut microbiome is a crucial modulator of visceral …
has received increasing attention. The gut microbiome is a crucial modulator of visceral …
[HTML][HTML] Altered microbiome composition in individuals with fibromyalgia
A Minerbi, E Gonzalez, NJB Brereton, A Anjarkouchian… - Pain, 2019 - journals.lww.com
Fibromyalgia (FM) is a prevalent syndrome, characterised by chronic widespread pain,
fatigue, and impaired sleep, that is challenging to diagnose and difficult to treat. The …
fatigue, and impaired sleep, that is challenging to diagnose and difficult to treat. The …
Key role of gut microbiota in anhedonia-like phenotype in rodents with neuropathic pain
C Yang, X Fang, G Zhan, N Huang, S Li, J Bi… - Translational …, 2019 - nature.com
Patients with chronic neuropathic pain frequently suffer from symptoms of anhedonia, which
is a core symptom of depression. Accumulating studies suggest that gut microbiota may play …
is a core symptom of depression. Accumulating studies suggest that gut microbiota may play …
Dominant role of the gut microbiota in chemotherapy induced neuropathic pain
C Ramakrishna, J Corleto, PM Ruegger, GD Logan… - Scientific reports, 2019 - nature.com
Chemotherapy induced peripheral neuropathy (CIPN), a toxic side effect of some cancer
treatments, negatively impacts patient outcomes and drastically reduces survivor's quality of …
treatments, negatively impacts patient outcomes and drastically reduces survivor's quality of …
Alterations in intestinal microbiota of colorectal cancer patients receiving radical surgery combined with adjuvant CapeOx therapy
C Kong, R Gao, X Yan, L Huang, J He, H Li… - Science China Life …, 2019 - Springer
An intricate relationship exists and interactions occur between gut microbiota and colorectal
cancer (CRC). Radical surgery combined with adjuvant chemotherapy (AC) serves as the …
cancer (CRC). Radical surgery combined with adjuvant chemotherapy (AC) serves as the …
Microbiota transplantation: targeting cancer treatment
X Wu, T Zhang, X Chen, G Ji, F Zhang - Cancer letters, 2019 - Elsevier
Mounting evidence have demonstrated that gut microbiota plays a critical role in cancer
patients' therapeutic responses to chemotherapy, radiotherapy and immunotherapy …
patients' therapeutic responses to chemotherapy, radiotherapy and immunotherapy …
Targeting strategies for chemotherapy-induced peripheral neuropathy: does gut microbiota play a role?
S Zhong, Z Zhou, Y Liang, X Cheng, Y Li… - Critical reviews in …, 2019 - Taylor & Francis
Chemotherapy-induced peripheral neuropathy (CIPN) is a progressive, often irreversible
condition that produces severe neurological deficits. Emerging data suggest that …
condition that produces severe neurological deficits. Emerging data suggest that …
The NOD2 signaling in peripheral macrophages contributes to neuropathic pain development
FV Santa-Cecília, DW Ferreira, RM Guimaraes… - Pain, 2019 - journals.lww.com
Neuropathic pain is one of the most important types of chronic pain. It is caused by neuronal
damage. Clinical and experimental studies suggest a critical role for neuroimmune …
damage. Clinical and experimental studies suggest a critical role for neuroimmune …