Health benefits of resveratrol: Evidence from clinical studies

AP Singh, R Singh, SS Verma, V Rai… - Medicinal research …, 2019 - Wiley Online Library
Resveratrol is a polyphenolic nutraceutical that exhibits pleiotropic activities in human
subjects. The efficacy, safety, and pharmacokinetics of resveratrol have been documented in …

Insulin resistance and atherosclerosis: implications for insulin-sensitizing agents

A Di Pino, RA DeFronzo - Endocrine reviews, 2019 - academic.oup.com
Patients with type 2 diabetes mellitus (T2DM) are at high risk for macrovascular
complications, which represent the major cause of mortality. Despite effective treatment of …

[HTML][HTML] Measurement and clinical significance of lipid peroxidation as a biomarker of oxidative stress: oxidative stress in diabetes, atherosclerosis, and chronic …

F Ito, Y Sono, T Ito - Antioxidants, 2019 - mdpi.com
Endothelial dysfunction is one of the initial steps in the pathogenesis of atherosclerosis and
development of cardiovascular disease in patients with diabetes mellitus. Several risk …

Risk and management of pre-diabetes

JWJ Beulens, F Rutters, L Ryden… - European journal of …, 2019 - academic.oup.com
Type 2 diabetes mellitus (T2DM) is associated with a two-to four-fold increased risk of
developing cardiovascular disease (CVD) and microvascular complications, which may …

Considerations when using alpha-glucosidase inhibitors in the treatment of type 2 diabetes

MS Hedrington, SN Davis - Expert opinion on pharmacotherapy, 2019 - Taylor & Francis
ABSTRACT Introduction: Alpha-glucosidase inhibitors (AGIs)–oral antihyperglycemic drugs,
inhibit upper gastrointestinal enzymes that break down complex carbohydrates into glucose …

Predictive Value of Fasting Glucose, Postload Glucose, and Hemoglobin A1c on Risk of Diabetes and Complications in Chinese Adults

J Lu, J He, M Li, X Tang, R Hu, L Shi, Q Su… - Diabetes …, 2019 - Am Diabetes Assoc
OBJECTIVE Uncertainty remains regarding the predictive value of various glycemic
measures as they relate to the risk of diabetes and its complications. Using the cutoffs …

[HTML][HTML] Sex differences in the association between diabetes and risk of cardiovascular disease, cancer, and all-cause and cause-specific mortality: a systematic …

Y Wang, A O'Neil, Y Jiao, L Wang, J Huang, Y Lan… - BMC medicine, 2019 - Springer
Background Studies have suggested sex differences in the mortality rate associated with
diabetes. We conducted a meta-analysis to estimate the relative effect of diabetes on the risk …

[HTML][HTML] Monocytes, macrophages, and metabolic disease in atherosclerosis

MC Flynn, G Pernes, MKS Lee… - Frontiers in …, 2019 - frontiersin.org
Atherosclerotic cardiovascular disease (CVD) is a lipid-driven chronic inflammatory disease,
in which macrophages are responsible for taking up these lipids and driving disease …

[HTML][HTML] Elucidating the mechanism of absorption of fast-acting insulin aspart: the role of niacinamide

J Kildegaard, ST Buckley, RH Nielsen… - Pharmaceutical …, 2019 - Springer
Purpose Fast-acting insulin aspart (faster aspart) is a novel formulation of insulin aspart
containing two additional excipients: niacinamide, to increase early absorption, and L …

Comparing different definitions of prediabetes with subsequent risk of diabetes: an individual participant data meta-analysis involving 76 513 individuals and 8208 …

CMY Lee, S Colagiuri, M Woodward… - BMJ Open Diabetes …, 2019 - drc.bmj.com
Objective There are currently five widely used definition of prediabetes. We compared the
ability of these to predict 5-year conversion to diabetes and investigated whether there were …