Why and where an HIV cure is needed and how it might be achieved
Despite considerable global investment, only 60% of people who live with HIV currently
receive antiretroviral therapy. The sustainability of current programmes remains unknown …
receive antiretroviral therapy. The sustainability of current programmes remains unknown …
[HTML][HTML] CD8+ T-cell response to HIV infection in the era of antiretroviral therapy
Although the combined antiretroviral therapy (cART) has decreased the deaths associated
with the immune deficiency acquired syndrome (AIDS), non-AIDS conditions have emerged …
with the immune deficiency acquired syndrome (AIDS), non-AIDS conditions have emerged …
Epigenetic signature of PD-1+ TCF1+ CD8 T cells that act as resource cells during chronic viral infection and respond to PD-1 blockade
We have recently defined a novel population of PD-1 (programmed cell death 1)+ TCF1 (T
cell factor 1)+ virus-specific CD8 T cells that function as resource cells during chronic LCMV …
cell factor 1)+ virus-specific CD8 T cells that function as resource cells during chronic LCMV …
Recurrent group A Streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant TFH cells
JM Dan, C Havenar-Daughton, K Kendric… - Science translational …, 2019 - science.org
“Strep throat” is highly prevalent among children, yet it is unknown why only some children
develop recurrent tonsillitis (RT), a common indication for tonsillectomy. To gain insights into …
develop recurrent tonsillitis (RT), a common indication for tonsillectomy. To gain insights into …
High-dimensional cell-level analysis of tissues with Ce3D multiplex volume imaging
W Li, RN Germain, MY Gerner - Nature protocols, 2019 - nature.com
Understanding the structure–function relationships between diverse cell types in a complex
organ environment requires detailed in situ reconstruction of cell-associated molecular …
organ environment requires detailed in situ reconstruction of cell-associated molecular …
Overexpression of T-bet in HIV infection is associated with accumulation of B cells outside germinal centers and poor affinity maturation
JW Austin, CM Buckner, L Kardava, W Wang… - Science translational …, 2019 - science.org
Nearly all chronic human infections are associated with alterations in the memory B cell
(MBC) compartment, including a large expansion of CD19hiT-bethi MBC in the peripheral …
(MBC) compartment, including a large expansion of CD19hiT-bethi MBC in the peripheral …
[HTML][HTML] CXCR5+ CD8 T cells: protective or pathogenic?
KM Valentine, KK Hoyer - Frontiers in immunology, 2019 - frontiersin.org
CD8 T cells are infrequently considered part of germinal center reactions. Yet, a distinct
CXCR5+ CD8 T cell subset identified within the B cell follicle and germinal center in …
CXCR5+ CD8 T cell subset identified within the B cell follicle and germinal center in …
IL-27 promotes the expansion of self-renewing CD8+ T cells in persistent viral infection
Chronic infection and cancer are associated with suppressed T cell responses in the
presence of cognate antigen. Recent work identified memory-like CXCR5+ TCF1+ CD8+ T …
presence of cognate antigen. Recent work identified memory-like CXCR5+ TCF1+ CD8+ T …
[HTML][HTML] Star nanoparticles delivering HIV-1 peptide minimal immunogens elicit near-native envelope antibody responses in nonhuman primates
Peptide immunogens provide an approach to focus antibody responses to specific
neutralizing sites on the HIV envelope protein (Env) trimer or on other pathogens. However …
neutralizing sites on the HIV envelope protein (Env) trimer or on other pathogens. However …
[HTML][HTML] Long-term persistence of anti-HIV broadly neutralizing antibody-secreting hematopoietic cells in humanized mice
AS Kuhlmann, KG Haworth, IM Barber-Axthelm… - Molecular Therapy, 2019 - cell.com
Broadly neutralizing antibodies (bNAbs) are among the most promising strategies to achieve
long-term control of HIV-1 in the absence of combination antiretroviral therapy. Passive …
long-term control of HIV-1 in the absence of combination antiretroviral therapy. Passive …