[HTML][HTML] Natural plants compounds as modulators of epithelial-to-mesenchymal transition

L Avila-Carrasco, P Majano… - Frontiers in …, 2019 - frontiersin.org
Epithelial-to-mesenchymal transition (EMT) is a self-regulated physiological process
required for tissue repair that, in non-controled conditions may lead to fibrosis …

[HTML][HTML] Cytochrome P450 enzymes: a driving force of plant diterpene diversity

U Bathe, A Tissier - Phytochemistry, 2019 - Elsevier
In plant terpene biosynthesis, oxidation of the hydrocarbon backbone produced by terpene
synthases is typically carried out by cytochrome P450 oxygenases (CYPs). The …

Rosemary leaf powder improved growth performance, immune and antioxidant parameters, and crowding stress responses in common carp (Cyprinus carpio) …

M Yousefi, SM Hoseini, YA Vatnikov, EV Kulikov… - Aquaculture, 2019 - Elsevier
The present study aimed to investigate the beneficial effects of dietary rosemary leaf powder
(RLP) as growth promotor and immunostimulant on plasma immunity as well as stress …

Baicalein and baicalin promote antitumor immunity by suppressing PD-L1 expression in hepatocellular carcinoma cells

M Ke, Z Zhang, B Xu, S Zhao, Y Ding, X Wu… - International …, 2019 - Elsevier
Abstract Blocking the PD-L1/PD-1 pathway to prevent the immune evasion of tumor cells is a
powerful approach for treating multiple cancers, including hepatocellular carcinoma (HCC) …

Carnosol Improved Lifespan and Healthspan by Promoting Antioxidant Capacity in Caenorhabditis elegans

C Lin, X Zhang, Z Su, J Xiao, M Lv… - … Medicine and Cellular …, 2019 - Wiley Online Library
Carnosol, a phenolic diterpene, is one of the main constituents of Rosmarinus. It is known to
possess a range of bioactivities, including antioxidant, anticancer, antimicrobial, and anti …

[HTML][HTML] Carnosol, a natural polyphenol, inhibits migration, metastasis, and tumor growth of breast cancer via a ROS-dependent proteasome degradation of STAT3

H Alsamri, H El Hasasna, Y Al Dhaheri, AH Eid… - Frontiers in …, 2019 - frontiersin.org
We have previously demonstrated that carnosol, a naturally occurring diterpene, inhibited in
vitro cell viability and colony growth, as well as induced cell cycle arrest, autophagy and …

Oleuropein‐induced apoptosis is mediated by mitochondrial glyoxalase 2 in NSCLC A549 cells: A mechanistic inside and a possible novel nonenzymatic role for an …

C Antognelli, R Frosini, MF Santolla… - Oxidative medicine …, 2019 - Wiley Online Library
Oleuropein (OP) is a bioactive compound derived from plants of the genus Oleaceae
exhibiting antitumor properties in several human cancers, including non‐small‐cell lung …

[HTML][HTML] Phytochemical combination PB125 activates the Nrf2 pathway and induces cellular protection against oxidative injury

BM Hybertson, B Gao, S Bose, JM McCord - Antioxidants, 2019 - mdpi.com
Bioactive phytochemicals in Rosmarinus officinalis, Withania somnifera, and Sophora
japonica have a long history of human use to promote health. In this study we examined the …

[HTML][HTML] Evaluation of the oxidative status of salami packaged with an active whey protein film

MA Andrade, R Ribeiro-Santos, M Guerra… - Foods, 2019 - mdpi.com
Active packaging aims to prolong food's shelf-life by directly interacting with the packaged
food. This type of packaging is characterized by having the active agent incorporated into …

Farnesyl pyrophosphate synthase as a target for drug development: Discovery of natural-product-derived inhibitors and their activity in pancreatic cancer cells

S Han, X Li, Y Xia, Z Yu, N Cai, SR Malwal… - Journal of Medicinal …, 2019 - ACS Publications
Human farnesyl pyrophosphate synthase (Homo sapiens FPPS, Hs FPPS) is a target for
treating bone resorption diseases and some cancers. Hs FPPS is potently inhibited by …