Induced pluripotent stem cells and their use in human models of disease and development
P Karagiannis, K Takahashi, M Saito… - Physiological …, 2019 - journals.physiology.org
The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …
Cell models and drug discovery for mitochondrial diseases
S Hu, Q Zhuang, Y Qiu, X Zhu, Q Yan - Journal of Zhejiang University …, 2019 - Springer
Mitochondrion is a semi-autonomous organelle, important for cell energy metabolism,
apoptosis, the production of reactive oxygen species (ROS), and Ca 2+ homeostasis …
apoptosis, the production of reactive oxygen species (ROS), and Ca 2+ homeostasis …
mRNA reprogramming of T8993G Leigh's syndrome fibroblast cells to create induced pluripotent stem cell models for mitochondrial disorders
HE Grace, P Galdun III, EJ Lesnefsky… - Stem cells and …, 2019 - liebertpub.com
Early molecular and developmental events impacting many incurable mitochondrial
disorders are not fully understood and require generation of relevant patient-and disease …
disorders are not fully understood and require generation of relevant patient-and disease …
[HTML][HTML] Disease modeling of bone marrow failure syndromes using iPSC-derived hematopoietic stem progenitor cells
MI Elbadry, JL Espinoza, S Nakao - Experimental Hematology, 2019 - Elsevier
Highlights•Induced pluripotent stem cells (iPSCs) can be generated from patients with bone
marrow failure syndromes (BMFSs).•Patient-derived iPSCs can generate hematopoietic …
marrow failure syndromes (BMFSs).•Patient-derived iPSCs can generate hematopoietic …
线粒体疾病细胞模型及其药物筛选
SY Hu, QQ Zhuang, Y Qiu, XF Zhu, QF Yan… - Journal of Zhejiang …, 2019 - jzus.zju.edu.cn
线粒体是一种半自主性细胞器, 不仅是细胞能量代谢的重要场所, 而且与细胞凋亡, 活性氧(ROS)
产生和Ca 2+ 稳态等密切相关. 线粒体DNA (mtDNA) 突变是线粒体疾病发生的重要原因. 当前 …
产生和Ca 2+ 稳态等密切相关. 线粒体DNA (mtDNA) 突变是线粒体疾病发生的重要原因. 当前 …
Recapitulating Hematopoietic Development in a Dish
K Vanuytsel, MH Steinberg, GJ Murphy - … of iPS Cells: Innovation in Medical …, 2019 - Springer
The ability to generate patient-specific, induced pluripotent stem cells (iPSCs) together with
the advent of gene-editing technologies has opened up a realm of opportunities for disease …
the advent of gene-editing technologies has opened up a realm of opportunities for disease …