Spectral complexity of 5-ALA induced PpIX fluorescence in guided surgery: a clinical study towards the discrimination of healthy tissue and margin boundaries in high …

L Alston, L Mahieu-Williame, M Hebert… - Biomedical optics …, 2019 - opg.optica.org
Gliomas are diffuse and hard to cure brain tumors. A major reason for their aggressive
behavior is their property to infiltrate the brain. The gross appearance of the infiltrative …

[HTML][HTML] Speckle modulation enables high-resolution wide-field human brain tumor margin detection and in vivo murine neuroimaging

D Yecies, O Liba, ED SoRelle, R Dutta, E Yuan… - Scientific reports, 2019 - nature.com
Current in vivo neuroimaging techniques provide limited field of view or spatial resolution
and often require exogenous contrast. These limitations prohibit detailed structural imaging …

[HTML][HTML] Optical signatures derived from deep UV to NIR excitation discriminates healthy samples from low and high grades glioma

H Mehidine, A Chalumeau, F Poulon, F Jamme… - Scientific Reports, 2019 - nature.com
Among all the tumors of the central nervous system (CNS), glioma are the most deadly and
the most malignant. Surgical resection is the standard therapeutic method to treat this type of …

NAD (P) H fluorescence lifetime measurements in fixed biological tissues

JV Chacko, KW Eliceiri - Methods and Applications in …, 2019 - iopscience.iop.org
Autofluorescence based fluorescence lifetime imaging microscopy (AF-FLIM) techniques
have come a long way from early studies on cancer characterization and have now been …

Multimodal imaging to explore endogenous fluorescence of fresh and fixed human healthy and tumor brain tissues

H Mehidine, M Sibai, F Poulon, J Pallud… - Journal of …, 2019 - Wiley Online Library
To complement a project toward label‐free optical biopsy and enhanced resection which the
overall goal is to develop a multimodal nonlinear endomicroscope, this multimodal …

Quantitative assessment of microenvironment characteristics and metabolic activity in glioma via multiphoton microscopy

N Fang, Z Wu, X Wang, Y Lin, L Li… - Journal of …, 2019 - Wiley Online Library
Tumor microenvironment and metabolic activity in gliomas are the important biomarkers to
evaluate the progression of gliomas. Many evidences have suggested that the targeting of …

Interrogation of glioma metabolism on macroscale by FLIM

MV Shirmanova, M Lukina, EB Kisileva… - … Microscopy in the …, 2019 - spiedigitallibrary.org
This paper presents ex-vivo investigation of the brain tumors, namely glioblastoma and
anaplastic astrocytoma, by macroscopic fluorescence lifetime imaging (FLIM) of …

Detecting benign uterine tumors by autofluorescence lifetime imaging microscopy through adjacent healthy cervical tissues

M Huang, Z Zhang, X Wang, Y Xie, Y Fei… - Journal of Innovative …, 2019 - World Scientific
The endogenous fluorophores such as reduced nicotinamide adenine dinucleotide
(phosphate)(NAD (P) H) and flavin adenine dinucleotide (FAD) in cells and tissues can be …

5-ALA induced PpIX fluorescence guided surgery: a clinical study of spectral complexity in healthy tissues and margin boundaries in high and low grade gliomas

L Alston, L Mahieu-Williame, M Hebert… - … on Biomedical Optics, 2019 - opg.optica.org
Gliomas are diffuse brain tumors still hardly curable due to the difficulties to identify their
margins. 5-ALA induced PpIX fluorescence measurements have enabled to gain in …

Comparison of brain tissue structures on histological slides and fluorescence microscopy images

H MEHIDINE, A Elise, A TAUZIEDE-ESPARIAT… - Optics and the …, 2019 - opg.optica.org
Comparison of brain tissue structures on histological slides and fluorescence microscopy
images Page 1 BW4A.6.pdf Biophotonics Congress: Optics in the Life Sciences Congress 2019 …