Investigation of inhibitory potential of quercetin to the pyruvate dehydrogenase kinase 3: Towards implications in anticancer therapy
Abstract Pyruvate dehydrogenase kinase 3 (PDK3) is a mitochondrial protein, has recently
been considered as a potential pharmacological target for varying types of cancer. Here, we …
been considered as a potential pharmacological target for varying types of cancer. Here, we …
Novel tetradentate Schiff base zinc (II) complex as a potential antioxidant and cancer chemotherapeutic agent: Insights from the photophysical and computational …
S Shahraki, MH Majd, A Heydari - Journal of Molecular Structure, 2019 - Elsevier
In this study a new N4 Schiff base ligand (SB) was synthesized via condensation reaction of
3, 4-diaminobenzophenone with diacetyl monoxime in 1: 2 M ratio. Moreover, the …
3, 4-diaminobenzophenone with diacetyl monoxime in 1: 2 M ratio. Moreover, the …
Inhibitory mechanism of novel allosteric inhibitor, Chinese bayberry (Myrica rubra Sieb. et Zucc.) leaves proanthocyanidins against α-glucosidase
Abstract α-Glucosidase is a key enzyme related to starch digestion and type-2 diabetes. In
the present study, the inhibition effect and the underlying mechanism of Chinese bayberry …
the present study, the inhibition effect and the underlying mechanism of Chinese bayberry …
Elucidating the binding propensity of naphthyl hydroxamic acid to human serum albumin (HSA): multi-spectroscopic and molecular modeling approach
R Agrawal, Y Thakur, M Tripathi, MK Siddiqi… - Journal of Molecular …, 2019 - Elsevier
The association of human serum albumin (HSA) and its interaction with drug and other novel
compound has garnered keen interest in designing and development for new compounds …
compound has garnered keen interest in designing and development for new compounds …
A comparative spectroscopic, surface plasmon resonance, atomic force microscopy and molecular docking studies on the interaction of plant derived conferone with …
The binding mechanism of conferone, a natural sesquiterpene-coumarin, on human and
bovine serum albumins (HSA/BSA), was studied using circular dichroism (CD), fluorescence …
bovine serum albumins (HSA/BSA), was studied using circular dichroism (CD), fluorescence …
Inhibitory kinetics and mechanism of rifampicin on α-glucosidase: Insights from spectroscopic and molecular docking analyses
MZ Lin, WM Chai, YL Zheng, Q Huang… - International journal of …, 2019 - Elsevier
Abstract α-Glucosidase is a critical enzyme associated with diabetes mellitus, and the
inhibitors of the enzyme play important roles in the treatment of the disease. In this study, the …
inhibitors of the enzyme play important roles in the treatment of the disease. In this study, the …
Albumin binding, antioxidant and antibacterial effects of cerium oxide nanoparticles
SZK Roudbaneh, S Kahbasi, MJ Sohrabi… - Journal of Molecular …, 2019 - Elsevier
Herein, the interaction of CeO 2 NPs with HSA was explored by fluorescence, CD, UV–vis
and molecular docking studies. Afterwards, the antioxidant activity of CeO 2 NPs against H 2 …
and molecular docking studies. Afterwards, the antioxidant activity of CeO 2 NPs against H 2 …
Interaction of noscapine with human serum albumin (HSA): A spectroscopic and molecular modelling approach
Noscapine hydrochloride (Nos), an opium derived anticancer agent manifests therapeutic
applications and is compliant to beneficial modifications. In this paper, we study its …
applications and is compliant to beneficial modifications. In this paper, we study its …
Stabilizing proteins to prevent conformational changes required for amyloid fibril formation
MK Siddiqi, P Alam, S Malik, N Majid… - Journal of Cellular …, 2019 - Wiley Online Library
Amyloid fibrillation is associated with several human maladies, such as Alzheimer's,
Parkinson's, Huntington's diseases, prions, amyotrophic lateral sclerosis, and type 2 …
Parkinson's, Huntington's diseases, prions, amyotrophic lateral sclerosis, and type 2 …
Disorder-to-helix conformational conversion of the human immunomodulatory peptide LL-37 induced by antiinflammatory drugs, food dyes and some metabolites
F Zsila, G Kohut, T Beke-Somfai - International journal of biological …, 2019 - Elsevier
The human antimicrobial and immunomodulatory peptide LL-37 is ubiquitously expressed
and secreted by epithelial cells of mucosal surfaces including the gastrointestinal tract, the …
and secreted by epithelial cells of mucosal surfaces including the gastrointestinal tract, the …