Nuclear pore complex (NPC)-mediated nucleocytoplasmic trafficking is essential for key
cellular processes, such as cell growth, cell differentiation, and gene regulation. The NPC …

How intracellular organelles acquire their characteristic sizes is a fundamental question in
cell biology. Given stereotypical changes in nuclear size in cancer, it is important to …

Nucleoporins (Nups) are involved in neural development, and alterations in Nup genes are
linked to human neurological diseases. However, physiological functions of specific Nups …

Nuclear pore complexes have emerged in recent years as chromatin-binding nuclear
scaffolds, able to influence target gene expression. However, how nucleoporins (Nups) exert …

The nuclear pore complex (NPC) forms a gateway for nucleocytoplasmic transport. The
outer ring protein complex of the NPC (the Nup107-160 subcomplex in humans) is a key …

Reassembly of the nuclear pore complex (NPC) at the end of mitosis is an important event
for eukaryotic nuclear function. In this study, we examined the dynamic behaviors of the …

Nucleoporins (Nups) are known to be functional in nucleo‐cytoplasmic transport, but the
roles of nucleoporins in nonproliferating cells, such as cardiac myocytes, are still poorly …

Abstract Background LRP5/6 are co-receptors in Wnt/β-catenin pathway. Recently, we
discovered multiple β-catenin independent functions of LRP5/6 in tumor cells and in the …

In higher eukaryotic cells, the nuclear envelope (NE) is composed of double nuclear
membranes studded with nuclear pore complexes (NPCs) and undergoes dynamic …

Highlights•Nup2 associates with mitotic chromatin in Aspergillus nidulans and
vertebrates.•Mitotic chromatin and NPCs are bridged by Nup2 for co-segregation.•Functions …