We describe a recently recognized disease entity, limbic-predominant age-related TDP-43
encephalopathy (LATE). LATE neuropathological change (LATE-NC) is defined by a …

Neurodegenerative diseases of the central nervous system progressively rob patients of
their memory, motor function, and ability to perform daily tasks. Advances in genetics and …

Lysosomes, single-membrane organelles defined by a uniquely strong acidic lumenal pH
and high content of acid hydrolases, are the shared degradative compartments of the …

Frontotemporal dementia (FTD) is a heterogeneous clinical syndrome associated with
frontotemporal lobar degeneration (FTLD) as a relatively consistent neuropathological …

Neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) and
frontotemporal dementia (FTD) are increasing in prevalence but lack targeted therapeutics …

Frontotemporal lobar degeneration with neuronal inclusions of the TAR DNA-binding protein
43 (FTLD-TDP) represents the most common pathological subtype of FTLD. We established …

TDP-43 is present in a high proportion of aged brains that do not meet criteria for
frontotemporal lobar degeneration (FTLD). We determined whether there are distinct TDP …

We review the literature on Tau and TDP-43 proteinopathies in aged human brains and the
relevant underlying pathogenetic cascades. Complex interacting pathways are implicated in …

Frontotemporal lobar degeneration (FTLD) is the second most common form of dementia
after Alzheimer's disease. The study and the dissection of FTLD is complex due to its clinical …

Objective Common variants near TMEM106B associate with risk of developing
frontotemporal dementia (FTD). Emerging evidence suggests a role for TMEM106B in …