Spatiotemporal gene expression programmes are orchestrated by transcriptional
enhancers, which are key regulatory DNA elements that engage in physical contacts with …

In eukaryotes, the genome does not exist as a linear molecule but instead is hierarchically
packaged inside the nucleus. This complex genome organization includes multiscale …

A large number of putative cis-regulatory sequences have been annotated in the human
genome, but the genes they control remain poorly defined. To bridge this gap, we generate …

The genomes of multicellular organisms are extensively folded into 3D chromosome
territories within the nucleus. Advanced 3D genome-mapping methods that combine …

In the interphase of the cell cycle, chromatin is arranged in a hierarchical structure within the
nucleus,, which has an important role in regulating gene expression,,–. However, the …

Numerous studies have shown that non-coding RNAs play crucial roles in the development
and progression of various tumor cells. Plasmacytoma variant translocation 1 (PVT1) mainly …

How spatial chromosome organization influences genome integrity is still poorly understood.
Here, we show that DNA double-strand breaks (DSBs) mediated by topoisomerase 2 (TOP2) …

While genetic variation at chromatin loops is relevant for human disease, the relationships
between contact propensity (the probability that loci at loops physically interact), genetics …

Chromatin loops connect regulatory elements to their target genes. They serve as bridges
between transcriptional regulation and phenotypic variation in mammals. However, spatial …

CCCTC-binding factor (CTCF) plays a key role in the formation of topologically associating
domains (TADs) and loops in interphase. During mitosis TADs are absent, but how TAD …