According to the free drug hypothesis only the unbound drug is available to act at
physiological sites of action, and as such the importance of plasma protein binding primarily …

Background: Many researchers have prepared and evaluated nanosponges and claimed
their advantages as an effective drug carrier, especially it was observed prominently in case …

This invention relates to agents that are inhibitors or acti vators of variant forms of
endogenous proteins and novel methods of identifying such variants. Of particular interest …

COJUAWICINQKFR-OHUIHDMLSA-N O= C (NC1= CC= CC (C (F)(F) F)= C1) C1= CC (/C=
N\NC2= NC (N3CCOCC3)= C (F) C= N2)= C (O) C (Cl)= C1 Chemical compound O= C …

Conclusiones: Erlotinib, imatinib, lapatinib, pazopanib, sorafenib y sunitinib, muestran gran
variabilidad interindividual en su exposición con altos porcentajes de variación en los …