Caloric restriction mimetics against age-associated disease: targets, mechanisms, and therapeutic potential
The increase in life expectancy has boosted the incidence of age-related pathologies
beyond social and economic sustainability. Consequently, there is an urgent need for …
beyond social and economic sustainability. Consequently, there is an urgent need for …
The role of ceramides in insulin resistance
E Sokolowska, A Blachnio-Zabielska - Frontiers in Endocrinology, 2019 - frontiersin.org
Resistance to insulin is a pathophysiological state related to the decreased response of
peripheral tissues to the insulin action, hyperinsulinemia and raised blood glucose levels …
peripheral tissues to the insulin action, hyperinsulinemia and raised blood glucose levels …
Metabolic messengers: ceramides
SA Summers, B Chaurasia, WL Holland - Nature metabolism, 2019 - nature.com
Ceramides are products of metabolism that accumulate in individuals with obesity or
dyslipidaemia and alter cellular processes in response to fuel surplus. Their actions, when …
dyslipidaemia and alter cellular processes in response to fuel surplus. Their actions, when …
Lipotoxicity plays a key role in the development of both insulin resistance and muscle atrophy in patients with type 2 diabetes
RCR Meex, EE Blaak, LJC van Loon - Obesity Reviews, 2019 - Wiley Online Library
Insulin resistance and muscle mass loss often coincide in individuals with type 2 diabetes.
Most patients with type 2 diabetes are overweight, and it is well established that obesity and …
Most patients with type 2 diabetes are overweight, and it is well established that obesity and …
Blood-brain barrier permeability and physical exercise
MA Małkiewicz, A Szarmach, A Sabisz… - Journal of …, 2019 - Springer
In this narrative review, a theoretical framework on the crosstalk between physical exercise
and blood-brain barrier (BBB) permeability is presented. We discuss the influence of …
and blood-brain barrier (BBB) permeability is presented. We discuss the influence of …
Impact of endurance and resistance training on skeletal muscle glucose metabolism in older adults
LA Consitt, C Dudley, G Saxena - Nutrients, 2019 - mdpi.com
Aging is associated with insulin resistance and the development of type 2 diabetes. While
this process is multifaceted, age-related changes to skeletal muscle are expected to …
this process is multifaceted, age-related changes to skeletal muscle are expected to …
Molecular mechanisms by which aerobic exercise induces insulin sensitivity
H Yaribeygi, SL Atkin… - Journal of cellular …, 2019 - Wiley Online Library
Insulin resistance is a key feature of Type 2 diabetes and an important therapeutic target to
address glycemic control to prevent diabetic complications. Lifestyle advice is the first step in …
address glycemic control to prevent diabetic complications. Lifestyle advice is the first step in …
Emerging pharmacological targets for the treatment of nonalcoholic fatty liver disease, insulin resistance, and type 2 diabetes
Type 2 diabetes (T2D) is characterized by persistent hyperglycemia despite
hyperinsulinemia, affects more than 400 million people worldwide, and is a major cause of …
hyperinsulinemia, affects more than 400 million people worldwide, and is a major cause of …
Application of metabolomics for unveiling the therapeutic role of traditional Chinese medicine in metabolic diseases
G Wu, W Zhang, H Li - Journal of Ethnopharmacology, 2019 - Elsevier
Ethnopharmacological relevance Traditional medicine has been practiced for thousands of
years in China and some Asian countries. Traditional Chinese Medicine (TCM) is …
years in China and some Asian countries. Traditional Chinese Medicine (TCM) is …
The role of dihydrosphingolipids in disease
Dihydrosphingolipids refer to sphingolipids early in the biosynthetic pathway that do not
contain a C4-trans-double bond in the sphingoid backbone: 3-ketosphinganine (3-ketoSph) …
contain a C4-trans-double bond in the sphingoid backbone: 3-ketosphinganine (3-ketoSph) …