Opioids have long held a prominent role in the management of perioperative pain in adults
and children. Published reports concerning the appropriate, and inappropriate, use of these …

Human renal membrane transporters play key roles in the disposition of renally cleared
drugs and endogenous substrates, but their ontogeny is largely unknown. Using 184 human …

Introduction: The opioid abuse epidemic and its toll on the adolescent population have
heightened awareness for safer opioid prescribing practices in pediatric pain management …

Morphine is commonly used for analgesia in the neonatal intensive care unit (NICU) despite
having highly variable pharmacokinetics (PKs) between individual patients. The …

Abstract Background and Objective Alemtuzumab (Campath®) is used to prevent graft-
versus-host disease and graft failure following pediatric allogeneic hematopoietic cell …

Objective Morphine is a commonly used drug in encephalopathic neonates treated with
therapeutic hypothermia after perinatal asphyxia. Pharmacokinetics and optimal dosing of …

Background: The emergence of coagulase-negative staphylococci with reduced vancomycin
susceptibility in some neonatal intensive care units has resulted in an increase of linezolid …

Objective To describe pain assessment, the pattern of analgesic and sedative drug use, and
adverse drug reactions in a neonatal intensive care unit (NICU) during the postsurgery …

Objectives: To develop a pharmacokinetic-pharmacogenomic population model of
midazolam in critically ill children with primary respiratory failure. Design: Prospective …

Objective: To develop a pharmacokinetic-pharmacogenomic population model of morphine
in critically ill children with acute respiratory failure. Design: Prospective pharmacokinetic …